Indian Journal of Pathology and Microbiology

BRIEF COMMUNICATION
Year
: 2015  |  Volume : 58  |  Issue : 4  |  Page : 479--482

Immunofluorescence profile of discoid lupus erythematosus


Shreekant Bharti1, Sunil Dogra2, Biman Saikia1, Ranjana Minz Walker1, Seema Chhabra1, Uma Nahar Saikia3 
1 Department of Immunopathology, PGIMER, Chandigarh, India
2 Department of Dermatology, PGIMER, Chandigarh, India
3 Department of Histopathology, PGIMER, Chandigarh, India

Correspondence Address:
Dr. Seema Chhabra
Department of Immunopathology, PGIMER, Sector-12, Chandigarh
India

The direct immunofluorescence (DIF) of skin in conjunction with histopathology gives the best diagnostic yield. It is invaluable in confirming the diagnosis of small vessel vasculitides and bullous lesions of the skin and can be used as an additional tool to pinpoint the diagnosis of systemic and localized autoimmune diseases involving the skin. This study was undertaken to analyze the strength of DIF vis-à -vis histopathology in the diagnosis of discoid lupus erythematosus (DLE) and at the same time to elaborate the specific immunofluorescence findings in the lesions of DLE. The clinical profile and cutaneous lesions of 75 patients with DLE are described. DIF was positive in 68% and histopathology in 60% of cases. The most common immunoreactant was IgG at the dermoepidermal junction, followed by IgM and IgA. A conclusive diagnosis of DLE could be achieved satisfactorily in 64 cases (85%) by a combination of the two techniques.


How to cite this article:
Bharti S, Dogra S, Saikia B, Walker RM, Chhabra S, Saikia UN. Immunofluorescence profile of discoid lupus erythematosus.Indian J Pathol Microbiol 2015;58:479-482


How to cite this URL:
Bharti S, Dogra S, Saikia B, Walker RM, Chhabra S, Saikia UN. Immunofluorescence profile of discoid lupus erythematosus. Indian J Pathol Microbiol [serial online] 2015 [cited 2019 Aug 23 ];58:479-482
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2015;volume=58;issue=4;spage=479;epage=482;aulast=Bharti;type=0