Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 59  |  Issue : 3  |  Page : 310--313

Expression of CD71 by flow cytometry in acute leukemias: More often seen in acute myeloid leukemia


Amit Pande, Pranav Dorwal, Dharmendra Jain, Neetu Tyagi, Simmi Mehra, Ritesh Sachdev, Vimarsh Raina 
 Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India

Correspondence Address:
Dr. Pranav Dorwal
Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Sector 38, Gurgaon - 122 001, Haryana
India

Background: CD71 is a marker that has been usually used for identifying dysplasia in the erythroid series. We have tried to evaluate the expression of CD71 in various types of acute leukemias. Materials and Methods: We studied 48 patients of acute leukemia, of which 25 were acute myeloid leukemia (AML), 13 were precursor B-acute lymphoblastic leukemia (B-ALL), 8 were T-ALL, and 2 were mixed phenotype acute leukemia (T/myeloid) as per the WHO classification. Results: We found that the expression of CD71 was most prevalent in AMLs (84%), followed by T-ALL (50%) and least in B-ALL (30%). Conclusion: This finding clearly shows the higher expression of CD71 in AMLs compared to other common type of leukemias, such as B- and T-ALL. We suggest that the high expression of CD71 in AMLs could be used as a diagnostic marker and may also be used for minimal residual disease analysis after further studies in posttreatment scenario. This study is the first of its kind in the South Asian population.


How to cite this article:
Pande A, Dorwal P, Jain D, Tyagi N, Mehra S, Sachdev R, Raina V. Expression of CD71 by flow cytometry in acute leukemias: More often seen in acute myeloid leukemia.Indian J Pathol Microbiol 2016;59:310-313


How to cite this URL:
Pande A, Dorwal P, Jain D, Tyagi N, Mehra S, Sachdev R, Raina V. Expression of CD71 by flow cytometry in acute leukemias: More often seen in acute myeloid leukemia. Indian J Pathol Microbiol [serial online] 2016 [cited 2019 Jul 23 ];59:310-313
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2016;volume=59;issue=3;spage=310;epage=313;aulast=Pande;type=0