Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 60  |  Issue : 1  |  Page : 8--14

Calretinin expression as a reliable prognostic marker in different molecular subtypes of breast carcinoma


Mayada Saad Farrag1, Amro Awad El-karef2, Maha Mohammed Amin2, Nagwa Mokhtar Helal2, Omar Farouk Ali3, Nesrine Saad Farrag4 
1 Department of Pathology, Port Said Faculty of Medicine, Port Said University, Port Said, Egypt
2 Department of Pathology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt
3 Department of Oncology Surgery, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt
4 Department of Community Medicine and Public Health, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
Mayada Saad Farrag
Department of Pathology, Port Said Faculty of Medicine, Port Said University, Port Said
Egypt

Background: Calretinin (CR), a known mesothelial marker, is expressed in both epithelial and mesenchymal malignancies including breast cancer. Aims: We aimed to measure the frequency of CR expression in correlation with other clinicopathological parameters of different molecular subtypes of invasive breast carcinoma and to study its prognostic implications in this common cancer.Study Design: Tissue microarrays were constructed from 225 tissue samples of breast carcinoma cases. Subjects and Methods: Immunostaining for CR in addition to estrogen receptors, progesterone receptors, human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor, CK5/6, and Ki-67 for molecular subtyping. Statistical Analysis Used: Chi-square and Fisher's exact tests were done using SPSS 18.0 software (IBM Inc.). Survival data were analyzed using Kaplan–Meier test, Log-rank test, and Cox proportional hazard models. Results: Cases of invasive breast carcinomas with different grades were classified into 84 luminal A, 45 luminal B, 27 HER2 positive, 40 basal-like, and 29 unclassified. High CR expression was associated with tumors of high grade (P < 0.0001), high locoregional recurrence (P = 0.005), hormonal receptors negative, and high Ki-67 indices. They frequently display a basal-like phenotype (70%, P < 0.0001), HER2 (59.3%), and luminal B (33.3%) tumors compared to luminal A (9.5%) and unclassified subtypes (17.2%). Moreover, it is associated with poor overall patient survival (P = 0.034), but it does not affect disease-free survival. Conclusions: Calretinin could be a reliable predictor marker of adverse prognosis in breast cancer.


How to cite this article:
Farrag MS, El-karef AA, Amin MM, Helal NM, Ali OF, Farrag NS. Calretinin expression as a reliable prognostic marker in different molecular subtypes of breast carcinoma.Indian J Pathol Microbiol 2017;60:8-14


How to cite this URL:
Farrag MS, El-karef AA, Amin MM, Helal NM, Ali OF, Farrag NS. Calretinin expression as a reliable prognostic marker in different molecular subtypes of breast carcinoma. Indian J Pathol Microbiol [serial online] 2017 [cited 2017 May 26 ];60:8-14
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=1;spage=8;epage=14;aulast=Farrag;type=0