Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 60  |  Issue : 4  |  Page : 487--500

Spectrum of hepatobiliary cystic lesions: A 7-year experience at a tertiary care referral center in North India and review of literature


Prasenjit Das1, Pragya Sharma1, Tripti Nakra1, Shouriyo Ghosh1, Rajni Yadav1, Brijnandan Gupta1, Gaurav Khanna1, KS Madhusudhan2, Rajesh Panwar3, MK Anoop2, Ragini Kilambi3, Anand N Singh3, Nihar R Dash3, Sujoy Pal3, Siddhartha Datta Gupta1 
1 Department of Pathology, AIIMS, New Delhi, India
2 Department of Radiology, AIIMS, New Delhi, India
3 Department of GI Surgery, AIIMS, New Delhi, India

Correspondence Address:
Dr. Prasenjit Das
Department of Pathology, AIIMS, New Delhi
India

Context: Cysts arising from the hepatobiliary tree are a group of heterogeneous lesions with regard to pathogenesis, clinical presentation, and radiological finding. They can be intrahepatic or extrahepatic, developmental, secondary to infective/inflammatory etiologies, as well as neoplastic. This study was conducted to determine the spectrum of hepatobiliary cysts in surgically intervened cases, with regard to their prevalence, histological spectrum, and clinicoradiological correlation, wherever possible. Methods: In this retrospective observational study, hematoxylin and eosin stained slides of all cases of hepatobiliary cystic lesions, operated between 2009 and 2016 were reviewed. Special stains as reticulin, Masson's trichrome, and periodic acid Schiff were done wherever necessary. Overall prevalence, age-sex distribution, clinical presentation and histopathological patterns were studied. Relevant imaging findings were correlated wherever possible. Results: A total of 312 cases of hepatobiliary cysts were identified, the majority in females. Choledochal cysts (CCs) were the most common type (n = 198,63.5%), followed by hydatid cysts (n = 73,23.3%), simple hepatic cysts (n = 10,3.2%), congenital hepatic fibrosis (n = 10,3.2%), biliary cystadenomas (n = 4,1.2%) hepatic mesenchymal hamartomas (n = 7,2.2%), and cavernous hemangiomas (n = 3,0.9%). Fibropolycystic liver disease (n = 2,0.6%), Caroli's disease (n = 1, 0.3%), liver abscess (n = 2, 0.6%), infantile hemangioendothelioma (n = 1,0.3%), and biliary cystadenocarcinomas (n = 1,0.3%) were rare. Lesions noted mostly in 1st decade of life were: CCs, fibrocystic liver disease, Caroli's syndrome, cystic mesenchymal hamartoma, and infantile hemangioendotheliomas. Conclusion: In our cohort of surgically intervened cases of hepatobiliary cystic lesions from a tertiary care hospital in North India, the CCs, followed by hydatid cyst were the most common lesions. Histology can play vital role in characterization, as often clinical findings and radiology can overlap.


How to cite this article:
Das P, Sharma P, Nakra T, Ghosh S, Yadav R, Gupta B, Khanna G, Madhusudhan K S, Panwar R, Anoop M K, Kilambi R, Singh AN, Dash NR, Pal S, Gupta SD. Spectrum of hepatobiliary cystic lesions: A 7-year experience at a tertiary care referral center in North India and review of literature.Indian J Pathol Microbiol 2017;60:487-500


How to cite this URL:
Das P, Sharma P, Nakra T, Ghosh S, Yadav R, Gupta B, Khanna G, Madhusudhan K S, Panwar R, Anoop M K, Kilambi R, Singh AN, Dash NR, Pal S, Gupta SD. Spectrum of hepatobiliary cystic lesions: A 7-year experience at a tertiary care referral center in North India and review of literature. Indian J Pathol Microbiol [serial online] 2017 [cited 2020 Jul 7 ];60:487-500
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2017;volume=60;issue=4;spage=487;epage=500;aulast=Das;type=0