Indian Journal of Pathology and Microbiology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 61  |  Issue : 1  |  Page : 18--21

Evaluation of the osteopontin in oral peripheral and central giant cell granuloma


Nihan Aksakalli 
 Department of Tumor Pathology, Istanbul University, Institute of Oncology, Istanbul, Turkey

Correspondence Address:
Nihan Aksakalli
Department of Tumour Pathology, Istanbul University, Institute of Oncology, Block A, Floor 2 Capa, 34093, Istanbul
Turkey

Aim: Peripheral giant cell granuloma (PGCG) and central giant cell granuloma (CGCG) of the jaws are benign proliferations of spindle-shaped mesenchymal cells and multinucleated giant cells. Despite the histopathologic similarities, they have markedly different clinical behavior. PGCG shows low recurrence rate whereas CGCG shows a variable clinical behavior ranging from nonaggressive lesions to aggressive lesions characterizing by pain, rapid growth, and high recurrence rate. Therefore, the aim of the study was to compare CGCG with PGCG by immunohistochemistry using Ki-67, osteopontin (OPN), and integrin αvantibodies. Subjects and Methods: Twenty PGCG and 20 CGCG were selected for immunohistochemical evaluation of OPN, integrin αv, and Ki-67 in multinucleated giant cells and mononucleated cells of PGCG and CGCG. Results: PGCG showed higher Ki-67 immunoreactivity in mononucleated cells compared to CGCG (P < 0.05). There was no reactivity with Ki-67 in multinucleated giant cells of both groups. Mononucleated cells in CGCGs demonstrated increased OPN and integrin αvexpressions in comparison with PGCGs (P < 0.05). Conclusions: The clinic behavior of CGCG being more aggressive than PGCG might be explained by the high expression of OPN and integrin αv. Further studies are necessary to evaluate the other OPN receptors and their role on the biologic behavior of these lesions.


How to cite this article:
Aksakalli N. Evaluation of the osteopontin in oral peripheral and central giant cell granuloma.Indian J Pathol Microbiol 2018;61:18-21


How to cite this URL:
Aksakalli N. Evaluation of the osteopontin in oral peripheral and central giant cell granuloma. Indian J Pathol Microbiol [serial online] 2018 [cited 2019 Oct 18 ];61:18-21
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=1;spage=18;epage=21;aulast=Aksakalli;type=0