Indian Journal of Pathology and Microbiology

CASE REPORT
Year
: 2018  |  Volume : 61  |  Issue : 2  |  Page : 271--274

An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement


Anuj Verma, Sridhar Epari, Sumeet Gujral, Tanuja Shet 
 Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Sridhar Epari
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai - 400 012, Maharashtra
India

Rearrangements involving interferon regulatory factor 4 (IRF4) gene has been recently described in a subtype of diffuse large B-cell lymphoma (DLBCL). They occur in a typical clinical setting of a pediatric age group, predominantly with tonsillar mass, usually as a low-stage disease and with good response to chemotherapy. Histomorphologically, they show nodular/follicular architecture with diffuse strong immunopositivity for multiple myeloma oncogene 1. Here, the authors describe one such unusual case of large B-cell lymphoma with IRF4 gene rearrangement in a young child with the unusual location of inguinal region and detailed pathological (histological, immunohistochemical, and molecular) findings.


How to cite this article:
Verma A, Epari S, Gujral S, Shet T. An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement.Indian J Pathol Microbiol 2018;61:271-274


How to cite this URL:
Verma A, Epari S, Gujral S, Shet T. An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement. Indian J Pathol Microbiol [serial online] 2018 [cited 2020 Jul 5 ];61:271-274
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=271;epage=274;aulast=Verma;type=0