FROM EDITORíS DESK
Year : 2018 | Volume
: 61 | Issue : 4 | Page : 475--476
From Editor's desk
MD; FICPath; MIAC, DHA Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh
|How to cite this article:|
Agrawal R. From Editor's desk.Indian J Pathol Microbiol 2018;61:475-476
|How to cite this URL:|
Agrawal R. From Editor's desk. Indian J Pathol Microbiol [serial online] 2018 [cited 2019 May 24 ];61:475-476
Available from: http://www.ijpmonline.org/text.asp?2018/61/4/475/243011
The fourth issue of IJPM for this year (October-December 2018) is reaching you all. All the issues have been published are well within the time frame. Good numbers of article having great clinical significance, cases with presentation or unusual site feature in this issue.
For invasive cancers of breast, different predictive and prognostic factors have been reported. In the newer management system, target therapy forms the basis of effective treatment. Triple-negative breast cancer constitutes about one-fifth of the total new cases. These cases are associated with a younger age of presentation, advanced stage, increased risk of visceral metastasis, and grim outcome. They do not respond to conventional receptor-target-based treatment modalities. The numbers of CD4+ or CD8+ T-cells and the CD4/CD8 ratio at the tumor site in patient with breast cancer have great prognostic value. An original research article and a guest editorial on this topic feature in this issue.,
In the Indian population among males, lung carcinoma is the second-most common tumor and fifth-most common site affected. Article by Tiwari et al. on aldehyde dehydrogenase 1 expression in nonsmall cell lung cancer and its presence linked to a more tumorigenic nature with shorter disease-free survival in patients on platinum treatment is worth reading.
Autopsy carries importance in evaluating the cause of death, especially in the fetus. The most common cause for fetal death is respiratory disorders with majority due to aspiration pneumonitis, which if timely controlled can be prevented. Autopsy correlated with clinical data is important in evaluating fetal deaths further helping in reducing unexplained stillbirths.
Microsatellite instability (MSI) pathway is implicated in the carcinogenesis of colorectal carcinomas. Its status has important prognostic and therapeutic implications. The prevalence rate of colorectal carcinomas as a result of MSI in the Indian population has not been well documented. Nayak et al. reported a higher prevalence of MSI-high phenotype as compared to the previously published western literature with an emphasis on the need for more widespread testing resulting in better clinical management and identification of possible hereditary colon cancer syndrome.
Transurethral tumor resection forms the main treatment of patient with nonmuscle-invasive urothelial carcinoma. However, it is associated with a high recurrence rate and progression with the need for adjuvant therapy. Article by Elkady et al. highlights the use of some markers for predicting response to therapy as well as the clinical outcome of patients.
This issue includes an article on medical education which is of great significance nowadays. Peer-assisted teaching and learning is being experimented in different medical universities globally. It involves students through active learning strategies. For this to be effective, adequate transfer of knowledge through good peer teacher involvement, learner receptiveness, and sufficient contact time is needed. Adequate preparation, suitability of topics as per the type of activity, seminars, and course coherence are among the pre-requisites. Article by Grover et al. very meticulously highlight these facts.
Double malignancy with the involvement of a solid organ and hematopoietic system is rare. A case report by Pradhan and Sherpa. documents a metachronous tumor, with the secondary malignancy of acute myeloid leukemia occurring a few months after starting the treatment for the primary gastric carcinoma.
|1||Jagtap SV. Evaluation of CD4+ T-cells and CD8+ T-cells in triple-negative invasive breast cancer. Indian J Pathol Microbiol 2018;61:477-8.|
|2||Jafarian AH, Tasbandi A, Gilan H, Sheikhi M, Roshan NM. Evaluation of CD30/CD4/CD8 in triple-negative invasive ductal carcinoma of breast in association with clinicopathological prognostic factors. Indian J Pathol Microbiol 2018;61:500-4.|
|3||Tiwari N, Srivastava AN, Tandon N, Lal N, Yadav S, Kant S, et al. A prospective study of association of cancer stem cell marker aldehyde dehydrogenase 1 with clinicopathological profile in lung carcinoma patients. Indian J Pathol Microbiol 2018;61:89-94.|
|4||Neeha S, Kattimani SR, Mahanta AA, Patil AG. An autopsy based descriptive study of the spectrum of pulmonary lesions encountered in fetal deaths at a tertiary care center. Indian J Pathol Microbiol 2018;61:495-9.|
|5||Nayak SS, Roy P, Arora N, Arun I, Roy MK, Banerjee S, et al. Prevalence estimation of microsatellite instability in colorectal cancers using tissue microarray based methods: A tertiary care center experience. Indian J Pathol Microbiol 2018;61:520-5.|
|6||Elkady N, Sultan M, Elkhouly E. Evaluation of topoisomerase II, ki-67, and P53 expression in non-muscle- invasive urothelial carcinoma and their clinical significance. Indian J Pathol Microbiol 2018;61:526-31.|
|7||Grover S, Sood N, Chaudhary A. Student perception of peer teaching and learning in pathology: A qualitative analysis of modified seminars, fishbowls, and interactive classroom activities. Indian J Pathol Microbiol 2018;61:537-44.|
|8||Pradhan S, Sherpa M. Gastric carcinoma and acute myeloid leukemia: A case report of a double malignancy. Indian J Pathol Microbiol 2018;61:583-4.|