Indian Journal of Pathology and Microbiology

BRIEF COMMUNICATION
Year
: 2018  |  Volume : 61  |  Issue : 4  |  Page : 557--560

Chronic granulomatous disease presenting with small bone osteomyelitis in a young child: A case report


Preethi S Chari1, Prathap Chandra2, Sujay Prasad1, Sagar Bhattad3 
1 Hematopathology and Immunohematology, Anand Diagnostic Laboratory, Bengaluru, Karnataka, India
2 Department of Pediatrics, Motherhood Hospital, Bengaluru, Karnataka, India
3 Department of Pediatric Immunology, Aster CMI Hospital, Bengaluru, Karnataka, India

Correspondence Address:
Preethi S Chari
54, Bowring Tower, Bowring Hospital Road, Shivajinagar, Bengaluru - 560 001, Karnataka
India

Chronic granulomatous disease (CGD) is a life threatening inherited disorder with varied clinical presentations often characterized by recurrent bacterial and fungal infections along with widespread granulomatous tissue response. The disease results from phagocytic defects characterized by deficiencies in oxidative burst of neutrophils. Nitroblue tetrazolium reduction test (NBT) and Dihydrorhodamine (DHR) with PMA stimulation by flow cytometry are quick, simple, sensitive and specific laboratory tests that help establish early and reliable diagnosis of CGD with an overall improvement in survival and disease prognosis. We report a case of 2-year old child who presented with small bone osteomyelitis involving bilateral feet and was later diagnosed to have autosomal recessive CGD due to mutation in NCF1 gene.


How to cite this article:
Chari PS, Chandra P, Prasad S, Bhattad S. Chronic granulomatous disease presenting with small bone osteomyelitis in a young child: A case report.Indian J Pathol Microbiol 2018;61:557-560


How to cite this URL:
Chari PS, Chandra P, Prasad S, Bhattad S. Chronic granulomatous disease presenting with small bone osteomyelitis in a young child: A case report. Indian J Pathol Microbiol [serial online] 2018 [cited 2019 Dec 7 ];61:557-560
Available from: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=4;spage=557;epage=560;aulast=Chari;type=0