Indian Journal of Pathology and Microbiology

: 2019  |  Volume : 62  |  Issue : 2  |  Page : 193--194

From Editor's desk

Ranjan Agrawal 
 MD; FICPath; MIAC, DHA Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India

Correspondence Address:
Ranjan Agrawal
MD; FICPath; MIAC, DHA Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh

How to cite this article:
Agrawal R. From Editor's desk.Indian J Pathol Microbiol 2019;62:193-194

How to cite this URL:
Agrawal R. From Editor's desk. Indian J Pathol Microbiol [serial online] 2019 [cited 2019 Oct 23 ];62:193-194
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Full Text

Dear Readers,

The April–June 2019 issue of IJPM is well within the time frame. The articles published are high-quality ones from international as well as Indian authors. They are based on the recent advances as well as the newer perspective of pathological reporting. At this point of time, I would like to request the authors to mention their current affiliations while submitting their manuscripts for publication as against their previous ones.

Overexpression of trophoblast cell-surface antigen 2 in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior and helps in differentiating between the benign and malignant follicular thyroid lesions.[1] Papillary thyroid microcarcinoma is mostly asymptomatic and incidentally diagnosed during histopathology of thyroidectomy specimens. Senel et al. in their article emphasized the need for performing total thyroidectomies since fine-needle aspiration cytology has its limitations in differentiating benign from malignant follicular thyroid lesions, and furthermore, bilaterality and multifocality rates are well known in these tumors.[2]

Breast cancers in males are morphologically similar to those in females, but they behave biologically different. Immunophenotypically in males, there is more than 95% luminal A and B subtypes.[3] Angiogenesis has proved to play a vital role in both tumor growth and metastasis. CD105 expression is inversely related to tumor aggressiveness in clear cell renal cell carcinoma and can be used as a favorable prognostic marker. An article by Cioca et al. highlights the role of CD105 in assessing the microvascular density in various subtypes of renal cell carcinoma, thus selecting which group of patients would benefit from antiangiogenic treatment.[4]

GATA3 is a sensitive and specific marker, especially for urothelial carcinoma. Agarwal et al. in theirarticle have mentioned the use of GATA3 in biopsies with poor morphological characteristics for differentiating urothelial neoplasms from other genitourinary malignancies, thus helping in the proper management of such patients.GATA3 expression decreases with high-grade tumor, invasion, increasing nuclear pleomorphism, mitosis, presence of necrosis, and tumor-infiltrating lymphocytes.[5]

Prostate adenocarcinoma is one of the common cancers in males. Numerous prostatic and nonprostatic lesions and normal anatomical structures can mimic adenocarcinoma. A pathologist's awareness of such benign lesions morphologically similar to adenocarcinoma is important for the urologist. Mahapatra et al. have mentioned that routine hematoxylin and eosin staining is significant and immunohistochemistry should be used only for the gray zone lesions.[6]

Focal nodular hyperplasia of the liver is a benign nonneoplastic lesion commonly observed in adults. Its occurrence in children is rare. Histopathology along with glutamine synthetase immunostaining performed in doubtful cases differentiates hyperplasia from other pediatric liver masses, since management in both the conditions varies significantly.[7] Epstein–Barr virus has been implicated in inducing carcinomas of the upper aerodigestive tract and lymphomas, especially in immunocompromised patients. The virus also induces smooth muscle proliferation, mainly after transplantation. Vaideeswar and Yadav have reported an interesting case of multifocal miliary-sized leiomyomas in the lungs in a patient of renal transplant action diagnosed incidentally on autopsy.[8] Emperipolesis is an important and hallmark finding in Rosai–Dorfman disease. Rane et al. have reported a rare case of non-Hodgkin's lymphoma with extensive emperipolesis.[9]


1Sadullahoǧlu C, Sayıner A, Süren D, Yıldırım HT, Nergiz D, Sezer C, et al. The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions. Indian J Pathol Microbiol 2019;62:206-10.
2Senel F, Karaman H, Aytekin A, Silov G, Bayram A. Incidental papillary thyroid microcarcinomas in thyroidectomy specimens: A single-center experience from Turkey. Indian J Pathol Microbiol 2019;62:211-15.
3Pasricha S, Kamboj M, Tanwar P, Gupta G, Panigrahi M, Sharma A, et al. Immunophenotyping of male breast cancer-Experience at a tertiary care centre. Indian J Pathol Microbiol 2019;62:226-31.
4Cioca A, Muntean D, Bungardean C. CD105 as a tool for assessing microvessel density in renal cell carcinoma. Indian J Pathol Microbiol 2019;62:239-43.
5Agarwal H, Babu S, Rana C, Kumar M, Singhai A, Shankhwar SN, et al. Diagnostic utility of GATA3 immunohistochemical expression in urothelial carcinoma. Indian J Pathol Microbiol 2019;62:244-50.
6Mahapatra QS, Mohanty P, Nanda A, Mohanty L. Histomorphological study of prostatic adenocarcinoma and its mimics. Indian J Pathol Microbiol 2019;62:251-55.
7Islam N, Halder A, Ghosh R, Banerjee S, Mishra PK, Chatterjee U. Focal nodular hyperplasia of the liver in children: A report of 2 cases. Indian J Pathol Microbiol 2019;62:261-5.
8Vaideeswar P, Yadav S. Multifocal Epstein-Barr virus-associated miliary post-transplant smooth muscle tumors. Indian J Pathol Microbiol 2019;62:293-5.
9Rane SR, Parkhi M, Vishwasrao S, Nakate L. Non-Hodgkin's lymphoma with extensive emperipolesis mimicking Rosai-Dorfman disease: A rare case report. Indian J Pathol Microbiol 2019;62:319-22.