Indian Journal of Pathology and Microbiology

EDITORIAL
Year
: 2019  |  Volume : 62  |  Issue : 3  |  Page : 365-

From Editor's desk


Ranjan Agrawal 
 MD, FIC Path, MIAC, DHA, Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India

Correspondence Address:
Ranjan Agrawal
MD, FIC Path, MIAC, DHA, Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh
India




How to cite this article:
Agrawal R. From Editor's desk.Indian J Pathol Microbiol 2019;62:365-365


How to cite this URL:
Agrawal R. From Editor's desk. Indian J Pathol Microbiol [serial online] 2019 [cited 2019 Aug 19 ];62:365-365
Available from: http://www.ijpmonline.org/text.asp?2019/62/3/365/263463


Full Text



Dear Readers,

Yet another issue of IJPM is now in front of you. I thank all the authors who have contributed articles to IJPM. Your valuable manuscripts add value to the journal. Not only we come across much new information but also are abreast with the latest. Kindly consider IJPM as your first-choice journal for submitting articles.

This year, we intend to publish a special issue on “Genito-Urinary-Gynecologic pathology including breast.” This issue will feature interesting articles on the topics including renal system with urinary bladder, male genital system, female genital system, and breast.

Molecular cloning nowadays forms an integral part of diagnosing cancer. The genomic DNA for ERCC1 was the first human DNA repair gene to be isolated by molecular cloning. During cell replication, the damage caused to the DNA is repaired by several pathways, thus finally protecting the material. During chemotherapy, if a particular pathway is deficient, it leads to nonrepair of the damaged tumor cell DNA, thus improving the therapeutic response of the drug in use. The article by Foda et al. has meticulously expressed the role of ERCC1 in colorectal adenoma-carcinoma sequence, giving an insight into its use in cancer.[1] The guest editorial by Bansal has further narrated the role of ERCC1 as a biomarker in good detail.[2]

The article by Gupta et al. has tried to evaluate metastatic brain tumors with unknown primary using a panel of immunohistochemical markers along with a clinicoradiological correlation.[3] I am sure that the readers would gain a lot from this article. Carcinoma of the gall bladder is one of the notorious malignancies with a high rate of invasion and poor outcome. Increased levels of Oct-4 cancer stem cell marker are now considered to be an indicator of malignant gall bladder lesions, thus affecting the stage and grade of tumor. Analysis of Oct-4 thus ultimately affects patient survival. The research publication by Fatima et al. illustrates these details.[4]

Gahlot et al. via their research publication generated an interest wherein it needs to be proved that the assessment of the functionality of the intestinal mucosal immune system may yield significant information regarding the pathogenesis of celiac disease.[5]

Many more of such interesting research articles are solicited from the readers.

Jai Hind!

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Foda AA, Paliceli A, Shebi A, Boldorini R, Elnaghi K, EI Hawary AK. Role of ERCC1 expression in colorectal adenoma- carcinoma sequence and relation to other mismatch repair proteins expression, clinicopathological features and prognosis in mucinous and non-mucinous colorectal carcinoma. Indian J Pathol Microbiol 2019;62:405-12.
2Bansal N. Biomarker for colorectal carcinoma-ERCC1-New kid on the block! Indian J Pathol Microbiol 2019;62:366-7.
3Gupta A, Chaturvedi S, Jha D, Chaturvedi M. Revisiting metastatic central nervous system tumors with unknown primary using clinicopathologial findings: A single neurosciences institutional study. Indian J Pathol Microbiol 2019;62:368-74.
4Fatima N, Srivastava AN, Nigam J, Tandon N, Ahmad R, Kumar V. Clinicopathologial correlation of cancer stem cell markers Oct-4 and CD 133 expression as prognostic factor in malignant lesions of gallbladder: An immunohistochemical study. Indian J Pathol Microbiol 2019;62:384-90.
5Gahlot GP, Das P, Baloda V, Singh A, Vishnubhatia S, Gupta SD, et al. Duodenal mucosal immune cells in treatment-naïve adult patients with celiac disease having different histological grades and controls. Indian J Pathol Microbiol 2019;62:399-404.