Year : 2020 | Volume
: 63 | Issue : 1 | Page : 1--2
From Editor's desk
Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh
|How to cite this article:|
Agrawal R. From Editor's desk.Indian J Pathol Microbiol 2020;63:1-2
|How to cite this URL:|
Agrawal R. From Editor's desk. Indian J Pathol Microbiol [serial online] 2020 [cited 2020 Jun 5 ];63:1-2
Available from: http://www.ijpmonline.org/text.asp?2020/63/1/1/277437
Wishing you all a Happy and Prosperous New Year 2020. As we move ahead, we take along with us a basket of unaccomplished work and sweet–sour memories from the past. IJPM has moved to newer heights with a record number of articles submitted in 2019. The turnaround time in all the phases has been reduced tremendously. I reiterate my appeal to everyone to submit more and more of their original articles to IJPM. There is no dearth of research work in any Institution, but what is required is to pen them down and publish.
The January–March 2020 issue of IJPM contains rich blend of good articles with high academic impact. An article by Agarwal et al. emphasizes the fact that chronic tobacco exposure is known to induce carcinogenesis. In their study, they used tissue microarray for immunohistochemical identification of the molecular markers TIMP1, EPS8, and AXL kinase in oral and oropharyngeal squamous cell carcinomas. Identification of these markers helps in instituting an early treatment and provides a better prognosis in such patients.
Incidence of carcinoma breast is increasing in recent time maybe due to an increase in the occurrence or maybe due to the availability of better diagnostic facilities. Various markers for early and definite diagnosis are now available. However, regarding the pathogenesis, limited studies are available. Varma et al. have detected an association between beta-catenin and cyclin D1 in carcinoma breast as well as in the precursor lesions, indicating molecular pathogenesis, thus helping in planning for targeted therapy. Thus, their study highlights the role of both these markers to be of prognostic as well as predictive significance.
An independent prognostic factor in colorectal carcinoma is tumor budding which is not related to the TNM staging. It also correlates with the tumor aggressiveness. Lgr5 is reported to be involved in carcinogenesis of colorectal cancer. Expression of Lgr5 not only is related to the morphologic features but also is related to the tumor invasion. A research study by Sadek et al. aptly describes these features. Caroli Bottino et al., in their study, have highlighted the importance of CD57 in evaluating hepatic masses and have concluded to include it as a routine diagnostic test along with synaptophysin and chromogranin A.
Guleria et al. have in detail studied ovarian granulosa cell tumors. They not only mentioned the histopathological characteristics but also stated that the presence of nuclear grooves indicates granulosa cell origin, but Call–Exner bodies as was thought earlier do not confirm this origin. The study also mentions that Ki-67 carries an important role in the prognostication of granulosa cell tumors.
Shetty et al. in their extensive research on synovial sarcoma, a chemotherapy-sensitive tumor, have compared the different techniques of translocation detection such as fluorescence in-situ hybridization, reverse transcriptase PCR, INI 1, and fragment analysis. They reported that fragment analysis forms an important futuristic technique of detecting the translocation abnormality in synovial sarcoma. Epstein–Barr virus (EBV) can occasionally cause T-cell lymphoproliferative disorders in children. Keow et al. in their study meticulously highlighted the different manifestations caused by EBV.
As is evident from the Editorial, this issue contains a variety of multidisciplinary articles, and you can choose as per your field of interest. I request you all to cite articles published in IJPM whenever and wherever you plan to publish. Wishing you all a happy reading.
|1||Agarwal A, Garg C, Ganesh MS, Reddy S. Molecular mechanisms of tobacco induced oral and oropharyngeal cancer: Results of a tissue microarray and immunohistochemistry-based study from a tertiary cancer center in India. Indian J Pathol Microbiol 2020;63:7-12.|
|2||Varma K, Chauhan A, Bhargava M, Misra V, Srivastav S. Association of different patterns of expression of beta-catenin and cyclin D1 with pathogenesis of breast carcinoma. Indian J Pathol Microbiol 2020;63:13-8.|
|3||Sadek SA, Rehim DM, Fatima S. The role of tumor budding in colorectal adenocarcinoma: Possible involvement of the intestinal cancer stem cell marker Lgr5. Indian J Pathol Microbiol 2020;63:32-7.|
|4||Caroli Bottino A, Mauricio AS, Pannain VL. CD57 as a routine neuroendocrine marker for liver metastasis. Indian J Pathol Microbiol 2020;63:38-43.|
|5||Guleria P, Kumar L, Kumar S, Bhatla N, Ray R, Singhal S, et al. A clinicopathological study of granulosa cell tumors of the ovary: Can morphology predict prognosis? Indian J Pathol Microbiol 2020;63:53-9.|
|6||Shetty O, Pai T, Gurav M, Rekhi B. Comparison between fluorescence in-situ hybridization (FISH), reverse transcriptase PCR (RT-PCR) and fragment analysis, for detection of t (X; 18) (p11; q11) translocation in synovial sarcomas. Indian J Pathol Microbiol 2020;63:64-72.|
|7||Keow JY, Stecho WM, Haig AR, Sangle NA. EBV-positive T/NK-associated lymphoproliferative disorders of childhood: A complete autopsy report. Indian J Pathol Microbiol 2020;63:81-5.|