Year : 2020 | Volume
: 63 | Issue : 2 | Page : 169--170
From Editor's desk
MD; FIC Path; MIAC, DHA, Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh
|How to cite this article:|
Agrawal R. From Editor's desk.Indian J Pathol Microbiol 2020;63:169-170
|How to cite this URL:|
Agrawal R. From Editor's desk. Indian J Pathol Microbiol [serial online] 2020 [cited 2020 Aug 15 ];63:169-170
Available from: http://www.ijpmonline.org/text.asp?2020/63/2/169/282723
After the January and the special issue on genitourinary, gynae, and breast pathology, we are new up with the April issue. Submission to IJPM has always been multisectorial. Articles from all the fields and subspecialties are included in each issue printed. We have been receiving good feedbacks from our readers about the quality and scientific content of IJPM. We are trying our best to raise it much further ahead.
In this venture, we have included a review article on clear cell lesions by Kar. The presence of clear cells not only helps in the diagnosis but also may pose diagnostic challenge for the pathologists. These lesions can be observed in all the categories, i.e., neoplastic, both benign and malignant, and also in nonneoplastic pathologies. Different sites known to have reported clear cells include female genital and urogenital tracts, head and neck, neural system, skin, and, to a lesser extent, in the soft tissues and bone. Both carcinoma and sarcomas can result in clear cell morphology. Another point raised by Kar is a caution regarding the authenticity of the presence of clear cells, especially a greater chance of they being artifactual.
Carcinoma breast is an important area of research nowadays, especially since early diagnosis carries a better prognosis. Different markers are known to have separate but important roles that may help not only in the treatment part but also in assessing the outcome of therapy. Her 2/neu gene overexpression using dual-color dual-hapten in situ hybridization as against fluorescent in situ hybridization provides a better signaling as well as concordance rate. Immune response generated by the neoplastic cells may lead to accumulation of mast cells in the periphery of the breast cancer cells. Pyla et al. have reported that the number of mast cells observed were inversely proportional to the tumor grade. Vascular endothelial growth factor receptors are known to play a vital role in tumor growth. Microvessel density quantifies the angiogenic markers such as Flt-1 and Flt-4, which correlates well with the grade of ductal carcinoma breast.
Lee et al. have studied the role of ASXL1 as a tumor suppressor in colorectal cancer with the result that loss of ASXL1 expression is associated with metastasis to the lymph nodes along with invasion of the lymphatics. Diagnosing ovarian cancers is important, especially since they are fatal. Amanullah et al. have highlighted the varying patterns of expression and staining as seen in p53 in different epithelial ovarian tumors. The authors have further stressed on having a correct interpretation of the IHC marker p53.
Remote areas may face problem in using the latest microscopes with an inbuilt light source due to frequent power cuts. Mondal et al. published an article addressing this issue. They developed an indigenous stand for smartphones which would give a full illumination and serve as an alternate light source for the same microscope.
In this issue, we are not including the list of upcoming conferences since most of them have either been cancelled or postponed due to the pandemic of COVID-19. In the editorial insights, we have planned to make the readers aware of the various aspects of publishing that would help them get first-hand knowledge of the various traps. More of original articles are solicited from the authors. Furthermore, senior faculties are requested to volunteer for reviewing articles submitted to IJPM.
|1||Kar A. Clear cell lesions in pathology: Histomorphologic approach to diagnosis. Indian J Pathol Microbiol 2020;63:177-87.|
|2||Gajaria PK, Tambe S, Pai T, Patil A, Desai SB, Shet TM. Dualcolor dualhapten in situ hybridization (DDISH) – Comparison with fluorescence in situ hybridization (FISH) for HER2/neu testing in breast cancer. Indian J Pathol Microbiol 2020;63:194-9.|
|3||Pyla RD, Potekar RM, Patil VS, Reddy AK, Sathyashree KV. Quantitative mast cell analysis and hormone receptor study (ER, PR and HER2/neu) in invasive carcinoma of breast. Indian J Pathol Microbiol 2020;63:200-4.|
|4||Sakri MS, Rahman WF, Damitri TA, Din AT, Idris FM, Jaafar H. Microvessel density and vascular endothelial growth factor receptors in breast carcinoma under the influence of rapamycin and platelet factor 4. Indian J Pathol Microbiol 2020;63:205-9.|
|5||Lee JH, Lee JH, Ahn BK, Paik SS, Kim H, Lee KH. Loss of ASXL1 expression is associated with lymph node metastasis in colorectal cancer. Indian J Pathol Microbiol 2020;63:221-5.|
|6||Amanullah NA, Poothiode U, Vilasiniamma L. Expression of p53 in epithelial ovarian tumors. Indian J Pathol Microbiol 2020;63:235-40.|
|7||Mondal H, Mondal S, Das D. Development and applicability of a smartphone torch based emergency light source for microscopy. Indian J Pathol Microbiol 2020;63:258-61.|