Close
  Indian J Med Microbiol
 

Figure 1: (a-d) Morphological features of colorectal serrated lesions. (a) Hyperplastic polyps (HP) (b) Sessile serrated adenomas (SSA). (c) Traditional serrated adenomas (TSA). (d) TSA with fi liform and villus (H&E stain, ×200). (E--H) Serrated adenoma with diff erent types of dysplasia. (e) TSA with mild--moderate dysplasia. (f) TSA with moderate dysplasia. (g) and (h) Different regions in the same sections. (g) Filiform and villi in the gland with moderate dysplasia. (H) High grade intraepithelial neoplasia. (H&E stain, scale bar: 20 μm). (I-L) Immunohistochemistry showing expression of b-catenin in colorectal adenomas and CRC tissues. Positive IHC signals were visualized with DAB (3, 3¢-diamino-benzidine-tetrahydrochloride) (brown reaction product). All sections were counterstained with haematoxylin. (i) Positive staining on the membrane of epithelial cells of normal colorectal mucosa (light brown signals). (j) Positive staining on the cell membrane and with week cytoplasmic staining of TA (light brown signals). (k) Positive staining on the cell membrane and with stronger cytoplasmic and nuclei staining of TSA (dark brown signals). (l) Strongest positive staining in the cytoplasm and nuclei of CRC (dark brown and black signals). (Immunohistochemistry stain, scale bar: 20 μm)

Figure 1: (a-d) Morphological features of colorectal serrated lesions. (a) Hyperplastic polyps (HP) (b) Sessile serrated adenomas (SSA). (c) Traditional serrated adenomas (TSA). (d) TSA with fi liform and villus (H&E stain, ×200). (E--H) Serrated adenoma with diff erent types of dysplasia. (e) TSA with mild--moderate dysplasia. (f) TSA with moderate dysplasia. (g) and (h) Different regions in the same sections. (g) Filiform and villi in the gland with moderate dysplasia. (H) High grade intraepithelial neoplasia. (H&E stain, scale bar: 20 μm). (I-L) Immunohistochemistry showing expression of b-catenin in colorectal adenomas and CRC tissues. Positive IHC signals were visualized with DAB (3, 3¢-diamino-benzidine-tetrahydrochloride) (brown reaction product). All sections were counterstained with haematoxylin. (i) Positive staining on the membrane of epithelial cells of normal colorectal mucosa (light brown signals). (j) Positive staining on the cell membrane and with week cytoplasmic staining of TA (light brown signals). (k) Positive staining on the cell membrane and with stronger cytoplasmic and nuclei staining of TSA (dark brown signals). (l) Strongest positive staining in the cytoplasm and nuclei of CRC (dark brown and black signals). (Immunohistochemistry stain, scale bar: 20 μm)