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  Indian J Med Microbiol
 

Figure 2: Role of CD10 in normal (left panel) and tumoral (right panel) context with a CD10-enzymatic deregulation (upper (a) and middle (b) panel) or an alteration in the CD10 signaling (lower (c) panel). (a) Transformation of ECP and/or P induces the decrease of the CD10-enzymatic activity and/or the decrease of the number of CD10-expressing cells that induce the accumulation of peptides, normally cleaved by the CD10, which mediate the proliferation of progenitor cells. (b) Transformation of ECP induces their proliferation and an increase in CD10-expressing cells, which cleaved differentiating signaling peptides. (c) CD10 signaling deregulation in transformed ECP cells could block PTEN activity and induce cell growth by the activation of Akt pathway. BM: basal membrane; CP: common progenitors; ECM: extracellular matrix; ECP: early common progenitors; Fb: fibroblast; GPI: glycosylphosphatidylinositol; MC: mature cells; P: progenitors; PTEN: phosphatase and TENsin homolog; SC: stem cells; SMAC: smooth muscle actin cells; SMAP: smooth muscle actin progenitors. (Adapted with permission from Maguer-Satta V, Besançon R, Bachelard-Cascales E. Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem cells. 2011;29:389-96)

Figure 2: Role of CD10 in normal (left panel) and tumoral (right panel) context with a CD10-enzymatic deregulation (upper (a) and middle (b) panel) or an alteration in the CD10 signaling (lower (c) panel). (a) Transformation of ECP and/or P induces the decrease of the CD10-enzymatic activity and/or the decrease of the number of CD10-expressing cells that induce the accumulation of peptides, normally cleaved by the CD10, which mediate the proliferation of progenitor cells. (b) Transformation of ECP induces their proliferation and an increase in CD10-expressing cells, which cleaved differentiating signaling peptides. (c) CD10 signaling deregulation in transformed ECP cells could block PTEN activity and induce cell growth by the activation of Akt pathway. BM: basal membrane; CP: common progenitors; ECM: extracellular matrix; ECP: early common progenitors; Fb: fibroblast; GPI: glycosylphosphatidylinositol; MC: mature cells; P: progenitors; PTEN: phosphatase and TENsin homolog; SC: stem cells; SMAC: smooth muscle actin cells; SMAP: smooth muscle actin progenitors. (Adapted with permission from Maguer-Satta V, Besançon R, Bachelard-Cascales E. Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem cells. 2011;29:389-96)