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  Indian J Med Microbiol
 

Figure 3: CD10 signaling pathways. CD10 associates with p85, a PI3K subunit, and Lyn kinase indirectly prevents FAK activation by PI3K. Simultaneously, the association between CD10 and the tumor suppressor PTEN simultaneously leads to decreased PIP3 phosphorylation, which activates the Akt pathway. CD10 catalytically inactivates a variety of peptides like bombesin in prostate cancer cells, which induces FAK or Rho signaling by their fixation onto G-coupled protein receptor. CD10 also cleaves growth factors such as fibroblast growth factor 2 (FGF2), which induces Akt signaling in favor of endothelial cell growth and angiogenesis. (Adapted with permission from Maguer-Satta V, Besançon R, Bachelard-Cascales E. Concise review: Neutral endopeptidase (CD10): A multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem cells. 2011;29:389-96.)

Figure 3: CD10 signaling pathways. CD10 associates with p85, a PI3K subunit, and Lyn kinase indirectly prevents FAK activation by PI3K. Simultaneously, the association between CD10 and the tumor suppressor PTEN simultaneously leads to decreased PIP3 phosphorylation, which activates the Akt pathway. CD10 catalytically inactivates a variety of peptides like bombesin in prostate cancer cells, which induces FAK or Rho signaling by their fixation onto G-coupled
protein receptor. CD10 also cleaves growth factors such as fibroblast growth factor 2 (FGF2), which induces Akt signaling in favor of endothelial cell growth and angiogenesis. (Adapted with permission from Maguer-Satta V, Besançon R,
Bachelard-Cascales E. Concise review: Neutral endopeptidase (CD10): A multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem cells. 2011;29:389-96.)