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  Indian J Med Microbiol
 

Figure 2: The large polyhedral cells are arranged in brain matter infiltrating nests and cords separated by thin fibrous septae, in an almost lobular architecture, showing moderate pleomorphism with focal areas of increased cellularity and nuclear pleomorphism. No spindle-shaped or epithelioid cells and no pigmentation are present. (a) The cells show discernible cytoplasmic membranes, a foamy, clear, or finely vacuolated cytoplasm with occasional pale eosinophilic granules, central, or eccentrically placed round to ovoid, size varying nuclei, many exhibiting prominent nucleoli, highly irregular chromatin content or occasional intranuclear inclusions, and a low nuclear to cytoplasmic ratio, and are variably sized, ranging from 20 to 70 microns in diameter. (b) Variable, mild to strong, perinuclear, cytoplasmic staining reaction for Melan-A (c) and HMB-45 (d). (a: H and E, ×100; b: H and E, ×400; c and d: IHC, ×100)

Figure 2: The large polyhedral cells are arranged in brain matter infiltrating nests and cords separated by thin fibrous septae, in an almost lobular architecture, showing moderate pleomorphism with focal areas of increased cellularity and nuclear pleomorphism. No spindle-shaped or epithelioid cells and no pigmentation are present. (a) The cells show discernible cytoplasmic membranes, a foamy, clear, or finely vacuolated cytoplasm with occasional pale eosinophilic granules, central, or eccentrically placed round to ovoid, size varying nuclei, many exhibiting prominent nucleoli, highly irregular chromatin content or occasional intranuclear inclusions, and a low nuclear to cytoplasmic ratio, and are variably sized, ranging from 20 to 70 microns in diameter. (b) Variable, mild to strong, perinuclear, cytoplasmic staining reaction for Melan-A (c) and HMB-45 (d). (a: H and E, ×100; b: H and E, ×400; c and d: IHC, ×100)