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  Indian J Med Microbiol
 

Figure 2: (a) The photograph from spleen microscopically reveals diffuse proliferation of medium to large sized neoplastic lymphoid cells with intermingled histiocytes showing emperipolesis (better seen in the inset picture – 1000 × magnification). (b and c) These neoplastic lymphoid cells demonstrate membranous immunoreactivity for CD19 and CD20. (d) MUM1 immunostain displays nuclear positivity in 40%–50% of tumor cells. (e) Very focal BCL6 nuclear positivity in tumor cells is noted (<5%). (f) CD68-positive immunostain in histiocytes

Figure 2: (a) The photograph from spleen microscopically reveals diffuse proliferation of medium to large sized neoplastic lymphoid cells with intermingled histiocytes showing emperipolesis (better seen in the inset picture – 1000 × magnification). (b and c) These neoplastic lymphoid cells demonstrate membranous immunoreactivity for CD19 and CD20. (d) MUM1 immunostain displays nuclear positivity in 40%–50% of tumor cells. (e) Very focal BCL6 nuclear positivity in tumor cells is noted (<5%). (f) CD68-positive immunostain in histiocytes