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  Indian J Med Microbiol
 

Figure 1: (a) HPLC in the propositus showing the abnormal Hb peak (Hb Fontainebleau) at retention time 2.92 min (arrow) and (b) a sharp abnormal Hb peak 8.3% with a retention time of 4.67 min and an elevated Hb A2 value of 5.7% in the husband of the proband. The baby's HPLC findings (c) are similar to her father (b). (d) Sequencing of the alpha globin gene in the father of the propositus showing substitution of G by C in Hb Fontainebleau [a1-CD21 GCT>CCT (Ala→Pro)] (arrow)

Figure 1: (a) HPLC in the propositus showing the abnormal Hb peak (Hb Fontainebleau) at retention time 2.92 min (arrow) and (b) a sharp abnormal Hb peak 8.3% with a retention time of 4.67 min and an elevated Hb A<sub>2</sub> value of 5.7% in the husband of the proband. The baby's HPLC findings (c) are similar to her father (b). (d) Sequencing of the alpha globin gene in the father of the propositus showing substitution of G by C in Hb Fontainebleau [a1-CD21 GCT>CCT (Ala→Pro)] (arrow)