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  Indian J Med Microbiol
 

Figure 1: Different patterns of beta-catenin and cyclin D1 expression. (a) Strong membranous staining with faint granular cytoplasmic staining (IHC, ×40). (b) Grade 1: Loss of membranous staining (IHC, ×40). (c) Grade 2: LOM with brown granular cytoplasmic staining and without nuclear staining (IHC, ×40). (d) Grade 3: LOM with brown nuclear staining (IHC, ×40). (e) Cyclin D1 overexpression: Intense brown nuclear positivity in 40% cells (IHC, ×40). (f) LOM with cytoplasmic positivity in foci of ductal carcinoma in situ(IHC, ×40)

Figure 1: Different patterns of beta-catenin and cyclin D1 expression. (a) Strong membranous staining with faint granular cytoplasmic staining (IHC, ×40). (b) Grade 1: Loss of membranous staining (IHC, ×40). (c) Grade 2: LOM with brown granular cytoplasmic staining and without nuclear staining (IHC, ×40). (d) Grade 3: LOM with brown nuclear staining (IHC, ×40). (e) Cyclin D1 overexpression: Intense brown nuclear positivity in 40% cells (IHC, ×40). (f) LOM with cytoplasmic positivity in foci of ductal carcinoma<i> in situ</i>(IHC, ×40)