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  Indian J Med Microbiol
 

Figure 2: (a-f) Transformation into acute lymphoblastic leukemia. (a-c) Bone marrow aspirate: (a) Highly cellular marrow particles [Leishman stain: 400×]. (b) Diffuse infiltration by lymphoblasts. (c) Lymphoblasts with high N:C ratio, scant cytoplasm with single prominent nucleoli [Leishman stain: 400×]. (d-f) Immunophenotypic analysis: (d) Blasts with CD34 and HLADR positivity. (e) Blasts co-expressed B-cell markers CD10 and CD19. (f) B-lymphoblasts with cytoplasmic CD79a expression. Note the cytoplasmic MPO is negative

Figure 2: (a-f) Transformation into acute lymphoblastic leukemia. (a-c) Bone marrow aspirate: (a) Highly cellular marrow particles [Leishman stain: 400×]. (b) Diffuse infiltration by lymphoblasts. (c) Lymphoblasts with high N:C ratio, scant cytoplasm with single prominent nucleoli [Leishman stain: 400×]. (d-f) Immunophenotypic analysis: (d) Blasts with CD34 and HLADR positivity. (e) Blasts co-expressed B-cell markers CD10 and CD19. (f) B-lymphoblasts with cytoplasmic CD79a expression. Note the cytoplasmic MPO is negative