Indian Journal of Pathology and Microbiology
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Year : 1995  |  Volume : 38  |  Issue : 3  |  Page : 257-60

Pregnancy induced hypertension and antithrombin-III.

Department of Obstetrics and Gynaecology, Safdarjang Hospital, New Delhi

Correspondence Address:
M Srivastava
Department of Obstetrics and Gynaecology, Safdarjang Hospital, New Delhi

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Source of Support: None, Conflict of Interest: None

PMID: 8819656

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This study was undertaken to determine the coagulation profile of women with pregnancy induced hypertension and to evaluate the changes in the level of AT-III in pre-eclampsia and eclampsia and its correlation with severity of disease in order to evaluate if it can be used as a marker for severity of PIH. 119 women with PIH in the third trimester of pregnancy constituted the study group. Age and parity matched 25 normal pregnant and 25 non-pregnant women were taken as control group. No significant difference between the coagulation profile of non-pregnant and normal pregnant women was seen. There is evidence of consumption coagulopathy in PIH patients and AT-III activity shows a gradual and almost linear reduction in various groups ranging from normal pregnant women to eclampsia. Reduction in AT-III activity has positive correlation with PIH and it can be a useful marker for severity of PIH.

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