Indian Journal of Pathology and Microbiology
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Year : 1997  |  Volume : 40  |  Issue : 4  |  Page : 527-30

Acute myelofibrosis.

Department of Pathology, Christian Medical College, Ludhiana

Correspondence Address:
S Das
Department of Pathology, Christian Medical College, Ludhiana

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Source of Support: None, Conflict of Interest: None

PMID: 9444866

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Acute myelofibrosis is a rare disorder. Five such cases have been diagnosed out of 3,149 Bone Marrow (B.M) Aspirations and Trephine Biopsies studied over a period of eight and a half years. Four out of five patients were males and the other female. Their age ranged from 14-71 years. Neither splenomegaly not red cell poikilocytosis (tear drop cells) were prominant features. B.M. trephine biopsy showed increase of atypical megakaryocytes/megakaryoblasts and marked fibrosis. There was rapid downhill clinical course of the disease in all cases.

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