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Indian Journal of Pathology and Microbiology
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Year : 2000  |  Volume : 43  |  Issue : 1  |  Page : 61-4

P 53 and PCNA in Non Hodgkin's lymphoma--an immunohistochemical evaluation.


Department of Pathology, Dr. A.L. Mudaliar, Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600113

Correspondence Address:
U Burra
Department of Pathology, Dr. A.L. Mudaliar, Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai-600113

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Source of Support: None, Conflict of Interest: None


PMID: 12583422

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P 53 positivity and PCNA labelling index were studied in 50 cases of node based Non Hodgkin's lymphomas, P 53 positivity was observed in a spectrum of these disorders, suggesting that P 53 mutations play a role in the genesis of these tumours. P 53 positivity incresed from low through intermediate to high grade tumours and thus may be of prognostic value in these lesions. PCNA labelling index (LI) was higher in high grade tumours. P 53 and PCNA immunoreactivity showed a relationship in that PCNA LI was seen to be more than 30% in P 53 positive tumours. P 53 positivity appears to be related to the subtype and proliferation rate of NHL.


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