|
|
| Year : 2001 | Volume
: 44
| Issue : 1 | Page : 9-12 |
|
|
A study of the haematologic spectrum of myelodysplastic syndrome.
J Kini, U N Khadilkar, J P Dayal
Department of Pathology, Kottayam Medical College, Kottayam
Correspondence Address:
J Kini
Department of Pathology, Kottayam Medical College, Kottayam
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 12561987 
|
|
|
In 31 patients of myelodysplastic syndrome, RAEB-t was the commonest subtype (29%), and RARS, the lease common (6.4%); 19.4% were characterised as the unclassifiable (UC) group. Pallor was the dominant sign (90.3%). Low haemoglobin in RA & RARS (p<0.05), thrombocytopenia in RAEB-t (p<0.01) and high leuco/monocyte counts in CMML (p<0.001) were observed. Neutropenia occurred most frequently in RAEB & RAEB-t and circulating blasts in all cases of RAEB-t and CMML. Bicytopenia was the commonest finding (58.1%) and pancytopenia the least (16.1%). 84% of marrows were hypercellular and trilineage dysplasia was seen in 68% of patients. Megaloblastoid dyserythropoiesis was the predominant feature in all cases, dysgranulopoiesis in all cases of RAEB, RAEB-t and CMML, and micromegokaryocytes in all cases of RARS, RAEB & CMML were seen. RAEB-t and RAEB (33.3% each) were the predominant groups which progressed to leukemia, FAB AML-M2, being the commonest type (60%). |
|
|
|
| [PDF]* |
|
 |
|
