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Indian Journal of Pathology and Microbiology
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Year : 2007  |  Volume : 50  |  Issue : 3  |  Page : 640-3

Role of bone marrow trephine biopsy in the diagnosis of marrow involvement in Hodgkin's disease.


Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry

Correspondence Address:
R Subramanian
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry

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Source of Support: None, Conflict of Interest: None


PMID: 17883170

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Bone marrow involvement in Hodgkin's disease alters the stage and hence the prognosis and treatment modality. Seventy-six patients of biopsy proven Hodgkin's disease in whom a bone marrow aspiration and biopsy were done simultaneously at the time of diagnosis were included in the study. Bone marrow involvement was seen in 14 (18%) cases. All 14 cases were diagnosed on biopsy. Only one aspirate was suspicious of involvement. Rest was either diluted (28%) or was normal (64%). Eleven patients were upstaged from stage I, II and III to stage IV. All patients had cytopenia of one or more cell line. Increased fibrosis, necrosis and a polymorphic cellular infiltrate were associated findings in the marrow. We wish to highlight the importance of bone marrow trephine biopsy over aspirate in staging even clinically early stage Hodgkin's disease.


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