LGCmain
Indian Journal of Pathology and Microbiology
Home About us Instructions Submission Subscribe Advertise Contact e-Alerts Ahead Of Print Login 
Users Online: 657
Print this page  Email this page Bookmark this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2008  |  Volume : 51  |  Issue : 3  |  Page : 351-352

Is seroprevalence of anti-IGM CMV among blood donors relevant in India?


Department of Transfusion Medicine, Armed Forces Medical College, Pune - 411 040, India

Correspondence Address:
P K Gupta
Department of Transfusion Medicine, Armed Forces Medical College, Pune - 411 040
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.42509

Rights and Permissions

Background: Infection with cytomegalovirus (CMV) is more common in developing nations and the people belonging to the lower socioeconomic section of the society. The immunosuppressed population for whom CMV-seronegative blood products are requested is increasing due to advances in medical care. Aim: To study the prevalence of CMV antibodies among the different sexes and age groups in healthy blood donors. Materials and Methods: A retrospective study was done on 5600 serum samples stored frozen in a repository for CMV antibodies using the ELISA technique. Results: Five thousand three hundred and fifty (95.5%) were male and 250 (4.5%) were female. Four cases (0.071%) out of 5600 samples were positive for anti-IgM CMV with 95% Confidence Interval (95% C.I) of 0.02 - 0.17. Conclusion: In a developing country like India, screening for IgM antibody on a routine basis may not be feasible, given the likely positive yield to be low and the cost being high. It is recommended that in a tertiary care hospital, blood units to be transfused to neonates, organ transplant recipients, those suffering from malignancies and other immunocompromised patients should be screened for anti-IgM CMV or preventive strategies like universal leucodepletion to be implemented to decrease the transmission of CMV in these groups of patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed244603    
    Printed111    
    Emailed1    
    PDF Downloaded290    
    Comments [Add]    
    Cited by others 5    

Recommend this journal