Indian Journal of Pathology and Microbiology
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Year : 2008  |  Volume : 51  |  Issue : 3  |  Page : 461
Steroid cell tumor, NOS, of ovary

Department of Pathology, SRL Ranbaxy, 41 Millers Road, Bangalore, Karnataka, India

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How to cite this article:
Flynn A, Ravindranath S. Steroid cell tumor, NOS, of ovary. Indian J Pathol Microbiol 2008;51:461

How to cite this URL:
Flynn A, Ravindranath S. Steroid cell tumor, NOS, of ovary. Indian J Pathol Microbiol [serial online] 2008 [cited 2021 Oct 18];51:461. Available from: https://www.ijpmonline.org/text.asp?2008/51/3/461/42542


We would like to report a case of a 27-year-old lady who presented with amenorrhea and an ovarian mass. The tumor measured 6 4 3 cm. Capsule was intact. Cut section showed yellow solid areas. Microscopy revealed lobules of cells arranged in sheets and nests and separated by rich network of vascular sinusoids. Cells were mostly polyhedral with abundant eosinophilic cytoplasm [Figure 1]. Focal clear cell change was also noted. No mitoses or necrosis was seen. Incidental finding of scattered granulomata within and around the tumor was noted. We reported this case as steroid cell tumor, NOS, of ovary.

Since steroid cell tumor, NOS is a rare ovarian tumor (0.1%) and the average age of occurrence is 43 years, [1] we are reporting it for its rarity and the young age of presentation. Rare instances of isosexual precocious puberty in children and fetal and maternal virilization in a pregnant woman with this tumor have been recorded. [2] Symptoms depend upon type of hormone secreted by tumor. [2]

Around 40% of steroid cell tumors are known to be malignant. [1] Histological criteria for malignancy are severe nuclear atypia with two or more mitoses/HPF, necrosis, hemorrhage and tumor diameter >7 cm. Metastasis, however, is the only definite sign of malignancy. [2] Malignant steroid cell tumors exhibit positivity for inhibin and melanin - A. Our patient's tumor did not show any of the above said histologic criteria for malignancy and for the past year, is doing well on follow-up.

Differential diagnosis of steroid cell tumor includes extensively luteinized granulosa cell tumor, thecoma, clear cell carcinoma, metastatic renal cell carcinoma and lipid-rich Sertoli cell tumor. [1] All these were excluded before reaching our diagnosis of steroid cell tumor, NOS.

No literature was found about the presence of granulomata in and around the tumor. We are of the opinion that they could be part of tissue immune response to the tumor or they have occurred as a reaction to local hormone secretion by tumor cells.

   References Top

1.Young R, Clement PB, Scully R. Sternberg's diagnostic surgical pathology, 4 th ed. In : Mills SE, Carter D, Greenbaum JK, et al , editors. Philadelphia: Lippincott Williams and Wilkins; 2004. p. 2594-5.  Back to cited text no. 1    
2.Hayes MC, Scully RE. Ovarian steroid cell tumours, not otherwise specified (lipid cell tumours): A clinicopathologic analysis of 63 cases. Am J Surg Pathol 1987;11:835-45.  Back to cited text no. 2  [PUBMED]  

Correspondence Address:
Anita Flynn
C103, Chartered Coronet Apts, MICO Layout, Arekere, Bannerghatta Road, Bangalore - 560 076, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.42542

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  [Figure 1]

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