| CASE REPORT |
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| Year : 2008 | Volume
: 51
| Issue : 4 | Page : 546-547 |
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Acute erythroid toxicity in visceral leishmaniasis: A rare complication of antimonial therapy
Sunita Sharma1, Priya Malhan1, Mukta Pujani1, B Rath2
1 Department of Pathology, Lady Hardinge Medical College and Kalawati Saran Children Hospital, New-Delhi, India
2 Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children Hospital, New-Delhi, India
Correspondence Address:
Mukta Pujani
Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0377-4929.43757
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The spectrum of side-effects of sodium stibogluconate is well described, however, little is known regarding the acute erythroid toxicity caused by this drug. We hereby present a case with this unusual complication of antimonial therapy. A 6-year-old male with leishmaniasis was started on parenteral sodium stibogluconate. During the course of treatment, his hemoglobin (Hb) dropped from 7.2 g/dl to 3.5 g/dl. Bone-marrow aspirate showed karyorrhexis in many erythroid precursors with several Leishmania donovanii bodies. Sodium stibogluconate was stopped and amphotericin-B was started. Four days after the cessation of the antimonials, the patient's Hb improved to 5 gm/dl with a corrected reticulocyte count of 10% indicating bone-marrow erythroid regeneration. The exact mechanism of this acute erythroid toxicity of sodium stibogluconate remains unexplored. |
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