Indian Journal of Pathology and Microbiology
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Year : 2009  |  Volume : 52  |  Issue : 2  |  Page : 164-166

Apoptosis in premalignant and malignant squamous cell lesions of the oral cavity: A light microscopic study

1 Department of Pathology, JN Medical College, A.M.U., Aligarh, U.P, India
2 Department of ENT, JN Medical College, A.M.U., Aligarh, U.P, India

Correspondence Address:
Veena Maheshwari
Department of Pathology, JNMC, AMU, Aligarh, UP
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.48907

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Background: Oral cancers are a major health problem in India. Recently, parameters of cell proliferation and cell death have emerged as important diagnostic and prognostic tools. Aims: The aim was to study apoptosis in premalignant and malignant squamous cell lesions of the oral cavity and to evaluate its prognostic role in oral cancers. Materials and Methods: The study included 175 patients presenting with oral lesions. Evaluation of apoptotic index (AI) (using light microscopy) was performed on hematoxylin and eosin-stained sections. Statistical Analysis Used: Student's t test was performed. Results: The mean AI increased progressively with increasing dysplasia, with the maximum AI in well-differentiated (WD) squamous cell carcinoma, and a fall was noted with progression toward higher grades. The difference between WD SCC and poorly-differentiated SCC was significant (P < 0.05). Cases with lymph node metastasis had significantly (P < 0.05) lower mean AI values. Conclusion: Apoptosis can be fairly accurately assessed using light microscopy. Tumors that exhibit less apoptosis tend to show aggressive behavior and have a greater potential for metastasis.

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