Indian Journal of Pathology and Microbiology
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Year : 2009  |  Volume : 52  |  Issue : 2  |  Page : 257-259

Transient leukemia

Department of Haematology, All India Institute of Medical Sciences, New Delhi - 110 029, India

Correspondence Address:
Renu Saxena
Department of Haematology, 1st Floor IRCH Building, All India Institute of Medical Sciences, Ansari Nagar, New Delih - 110 029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.48938

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A new born with a mongoloid slant, brachycephaly and low-set ears presented at birth with a total leucocyte count of 57 x 10 3 /L and the differential leucocyte count revealed 70% of these to be blasts. The morphology of the blasts was not characteristic of myeloid and lymphoid lineage. Cytochemistry showed myeloperoxidase (MPO), Sudan Black B (SBB), periodic acid-Schiff (PAS) and non-specific esterase (NSE) negativity. Flowcytometry showed blasts that were positive for CD-33, CD-34 and CD-7. On second follow-up on the 10th day, the same picture persisted on morphology. On subsequent follow-up, the blasts disappeared. This was thus confirmed to be a case with transient leukemia with Downs syndrome.

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