Indian Journal of Pathology and Microbiology
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Year : 2010  |  Volume : 53  |  Issue : 2  |  Page : 337-339

Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland

1 Department of Pathology, The Mission Hospital, Durgapur; Sector C, Immon Kalyan Sarani, Durgapur - 713212, India
2 Department of Pathology, SSKM Hospital, Kolkata, India
3 Department of Histopathology; Apollo Gleneagles Hospitals, 58 Canal Circular Road, Kolkata - 700 054, India

Correspondence Address:
R Ganguly
Department of Pathology, The Mission Hospital, Durgapur; Sector - 2C, Immon Kalyan Sarani, Durgapur - 713212
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.64328

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Various combinations of thyroid carcinomas have been reported including those between different cancers of follicular cell origin and those between follicular and C-cell histogenesis. Accordingly, anaplastic carcinomas have been seen to coincide with simultaneous papillary and follicular cancers. We report a case of composite anaplastic and papillary cancer on one thyroid lobe with a follicular carcinoma in the other lobe in a female patient aged 64 years. The patient also had a separate and independent follicular adenoma in the same lobe as the composite anaplastic and papillary carcinoma. The papillary carcinoma was continuous with the anaplastic carcinoma. The findings were supported by immunohistochemistry. The patient was managed by a total thyroidectomy with bilateral modified radical neck dissection followed by chemotherapy. However, she died two months after surgery. The common follicular cell origin will explain the concurrent presence of all these cancers. This could result from the dedifferentiation of a pre-existing differentiated carcinoma.

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