Indian Journal of Pathology and Microbiology
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LETTER TO EDITOR Table of Contents   
Year : 2010  |  Volume : 53  |  Issue : 2  |  Page : 372-373
Authors' reply

Department of Pathology, JSS Medical college, Mysore, India

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Date of Web Publication12-Jun-2010

How to cite this article:
Vanisri H R, Nandini N M, Sunila. Authors' reply. Indian J Pathol Microbiol 2010;53:372-3

How to cite this URL:
Vanisri H R, Nandini N M, Sunila. Authors' reply. Indian J Pathol Microbiol [serial online] 2010 [cited 2022 Jan 24];53:372-3. Available from: https://www.ijpmonline.org/text.asp?2010/53/2/372/64285


We appreciate the comments made by the reader and the interest shown in our article. (ref: Indian J Pathol Microbiol 2008;51:481-4.We agree that the smears stained with conventional (Romanovsky) stains only, show 'negative images' of acid fast bacilli and special stains can be used if suppurative morphology is seen in the needle aspirates. However, we disagree with the observation that the negative images of the mycobacteria were seen in our slide.

Negative images of mycobacteria are reported to be seen by many studies. But the mycobacteria should be seen on the subsequent Z-N staining. [1],[2] We have experience with them too [Figure 1] and [Figure 2]. In our article we have specifically noted that the Z-N staining was negative.

We reviewed the slides again and found neither refractile mycobacteria nor foam cells containing bacilli in the background. We feel that the reader might have misinterpreted the protein aggregates.

We once again thank the reader for the interest shown in our article.

   References Top

1.Maygarden SJ, Flanders EL, Mycobacteria can be seen as "negative images" in cytology smears from patients with acquired immunodeficiency syndrome. Mod Pathol 1990;3:415.   Back to cited text no. 1      
2.Iyengar KR, Basu D. Negative Images in the Fine Needle Aspiration Cytologic Diagnosis of Mycobacterial Infections. Malays J Pathol 2001;23:89-92.  Back to cited text no. 2  [PUBMED]    

Correspondence Address:
H R Vanisri
59/D5, II Main, II cross, Yadavagiri, Mysore - 570 020
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  [Figure 1], [Figure 2]


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