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CASE REPORT Table of Contents   
Year : 2010  |  Volume : 53  |  Issue : 3  |  Page : 529-531
Inflammatory myofibroblastic tumor parieto-occipital bone


1 Department of Pathology and Transfusion Medicine, Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS), Bangalore, India
2 Department of Pathology, Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS), Bangalore, India
3 Department of Radiology, Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS), Bangalore, India
4 Department of Neurosciences, Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS), Bangalore, India

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Date of Web Publication22-Oct-2010
 

   Abstract 

Inflammatory myofibroblastic tumor is a diverse group of lesions first described in lung and later on reported in various sites like stomach, bowel, spleen, bone. We report a case of inflammatory myofibroblastic tumor in a 30-year-old male who presented with a slowly progressive scalp swelling of two-year duration. Magnetic resonance imaging showed an intradiploic well enhancing lesion in parietal and occipital bone, isointense on T1 weighted images and hypo intense on T2 weighted images with dural enhancement. On histopathological examination, the lesion was composed of variable admixture of spindle cells with eosinophilic cytoplasm and inflammatory cells comprising of plasma cells and lymphocytes. The lesion was infiltrating the underlying dura. The spindle cells showed strong positivity for smooth muscle actin on immunohistochemistry. A final histopathologic diagnosis of inflammatory myofibroblastic tumor was rendered.

Keywords: Bone, inflammatory myofibroblastic tumor, parietal bone

How to cite this article:
Ghosal N, Roy R, Reddy K, Hegde A S. Inflammatory myofibroblastic tumor parieto-occipital bone. Indian J Pathol Microbiol 2010;53:529-31

How to cite this URL:
Ghosal N, Roy R, Reddy K, Hegde A S. Inflammatory myofibroblastic tumor parieto-occipital bone. Indian J Pathol Microbiol [serial online] 2010 [cited 2021 Aug 1];53:529-31. Available from: https://www.ijpmonline.org/text.asp?2010/53/3/529/68296



   Introduction Top


Inflammatory myofibroblastic tumor (IMT), also called earlier as inflammatory pseudo tumor, nodular lymphoid hyperplasia, plasma cell granuloma, are rare groups of lesions characterized histologically by acute and chronic inflammatory cells with variable degree of fibrous stroma. [1] Clinically and radiologically they may look like malignant tumors. First described in lungs; a large number of extra-pulmonary sites of IMT have been described in literature. [2],[3] We present a case of IMT of parieto - occipital bone in a young adult male with involvement of the dura.


   Case Report Top


A 30-year-old male presented with history of swelling in the left parieto-occipital region since two years. The swelling was slowly progressive with associated pain since the last one year. There was no history of seizures, nausea or vomiting. On examination the swelling measured 8 x 5 cm, was globular and hard in consistency. No sensory or motor deficits were noted. Computed tomography (CT) scanning revealed an osteolytic contrast enhancing lesion destroying the outer table of skull [Figure 1]a. No intracranial extension was seen. Magnetic resonance imaging (MRI) showed a well defined intra-diploic contrast enhancing lesion measuring 5.9 Χ 1.5 Χ 5.5 cm in the left parietal and occipital bone, isointense on T 1 weighted images and hypo intense on T 2 weighted images with dural enhancement [Figure 1]b. The underlying brain parenchyma was normal. A radiological impression of eosinophilic granuloma was given. Ultrasonography of the abdomen was normal. CT of the thorax was normal. The patient was taken for surgery and an enbloc excision of left parieto-occipital bony lesion with excision of dura followed by duroplasty and cranioplasty was done. The lesion was sent for histopathological examination.
Figure 1: (a) Computed tomography axial section showing a destructive osteolytic lesion of the parietal bone with destructi on of the outer table with a soft ti ssue mass overlying the defect, (b) Magnetic resonance
imaging showing well defi ned intradiploic contrast enhancing mass in the parietal bone with extension into the occipital bone


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Grossly, the lesion measured 7 Χ 7 Χ 2 cm, adherent to the scalp bone. The cut section was gray white and firm in consistency. Five micron thick sections were cut and stained with hematoxylin and eosin. On light microscopy, the tumor was composed of diffuse sheets of oval to spindle shaped cells intersected by fibro-collagenous bands [Figure 2]a. The cells showed moderate to abundant granular eosinophilic cytoplasm with nuclei showing convolution at places with a fine chromatin pattern [Figure 2]b. In addition, numerous plasma cells, few lymphocytes with lymphoid follicle formation at places and nutrophils were seen intermixed intimately with the tumor cells [Figure 3]a, b. A few cells showed crystalline substances in the cytoplasm. On immunohistochemistry, the cells showed strong positivity for smooth muscle actin and vimentin [Figure 4]a, b and focal positivity for epithelial membrane antigen in the plasma cells. The tumor was infiltrating the dura and involving the skull bone [Figure 5]. No meningothelial cells were seen. Due to the non-availability of anaplastic lymphoma kinase -1 antibody, we could not perform further tests for myofibroblastic differentiation. On the basis of the histomorphological features and immunohistochemistry a final diagnosis of inflammatory myofibroblastic tumor, parieto-occipital bone with infiltration into the underlying dura.
Figure 2: (a) Paraffi n secti on showing diffuse sheets of oval to spindle cells intersected by fibrocollagenous bands (H and E, ×100), (b) Paraffin section showing spindle shaped cells with dense eosinophilic cytoplasm (H and E, ×400)

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Figure 3: (a) Paraffin section plasma cells intermixed with the tumor cells (H and E, ×400), (b) Paraffi n secti on showing lymphocytes with follicle formation at places (H and E, ×100)

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Figure 4: Immunohistochemistry showing tumor cells positive for (a) smooth muscle actin and (b) vimenti n (Avidin Biotin Complex Immunoperoxidase, ×400)

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Figure 5: Paraffin section showing tumor involving the bone. (H and E, ×100)

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   Discussion Top


Inflammatory myofibroblastic tumor is currently accepted to be a true neoplasm with a wide spectrum of biological behavior, varying from benign lesions to the rare tumors which are multifocal and prone to recurrence. [4] Some researchers suggest the role of cytokines, particularly interleukins - 6 in its pathogenesis. [5]

IMT involving the central nervous system are described in various locations like cranial, spinal, and orbital. Most of these were dural based and radiologically showed two patterns: isolated mass forming and an en plaque pattern. [6] IMT in bone is very unusual, and there are only two cases reported, involving the temporal bone. [7] Gasparotti et al. [8] described a case of IMT in temporal bone in a young black patient, which on radiological imaging revealed a homogenously enhancing soft tissue mass of the right mastoid with bone erosion of the tegmen and extensive dural thickening. The present case lacked these clinical symptoms and presented solely with scalp swelling. The present case did not have pachymeningitis, cranial neuropathy or uveitis as described in the other case report. [9] Most of the bone IMT are osteolytic in appearance and a destructive bone lesion expanding into the soft tissue are well described, as was found in the present case. [7] However, it must be noted that it is very difficult, both clinically and radiologically, to decide whether a bone tumor with infiltration into the soft tissue is a pseudo-tumor or a true neoplasm. In our case, the lesion was first thought to be neoplasm such as meningioma, eosinophilic granuloma, metastasis, or an aggressive infectious process. In such instances, without a biopsy, differentiation between the above mentioned differential diagnosis is difficult. Tumors composed of myofibroblast and fibroblasts which pose significant challenge in differential diagnosis are aggressive fibromatosis, fibrosarcoma or other spindle cell malignancies. In fibromatosis, the spindle cells are more slender and there is more prominent collagenous tissue. The dense inflammatory component will be lacking in fibromatosis. Fibrosarcoma is a malignant tumor and will show herring bone pattern of arrangement of cells with mitotic activity. However, there is undoubtedly morphologic and clinical overlap between IMT and inflammatory fibrosarcoma. The question of distinction between the two rests on whether they are truly distinct or a part of neoplastic continuum of myofibroblastic proliferation with increasing cellular atypia and aggressiveness.

Our case showed histologic benign features like low cellularity, minimal nuclear atypia and no mitoses. Since it was a scalp tumor a differential diagnosis of eosinophilic granuloma, lymphoplasmacyte rich meningioma was also considered. However, no eosinophils or typical langerhans cell histiocytes with coffee bean nuclei were seen. No meningothelial clusters were seen and the spindle cells were negative for epithelial membrane antigen. MR imaging also showed extensive dural thickening and enhancement. Dural thickening and enhancement represent an unspecific reactive change to any adjacent dural lesion. They seem to be a common finding in IMT of the skull base, as reported by Han et al.[10] who observed intracranial dural involvement in all patients with fibrosing inflammatory pseudo tumors of the skull base.

The only effective treatment of IMT is complete surgical resection. Because of the higher recurrence rate, approaching 25% in extra pulmonary IMT, the patient has been kept on close follow-up.

 
   References Top

1.Coffin CM, Dehner LP, Meis-Kundblom JM. Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma and related lesion: A historical review with differential diagnostic considerations. Semin Diagn Pathol 1998;15:102-10.   Back to cited text no. 1      
2.Wreesmann V, van Eijck CH, Naus DC, van Velthuysen ML, Jeekel J, Mooi WJ. Inflammatory pseudo tumor (inflammatory myofibroblastic tumor) of the pancreas: A report of six cases associated with obliterative phlebitis. Histopathology 2001;38:105-10.   Back to cited text no. 2  [PUBMED]  [FULLTEXT]  
3.Pettinato G, Manivel JC, De Rosa N, Dehner LP. Inflammatory myofibroblastic tumor (plasma cell granuloma): Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol 1990;94:538-46.   Back to cited text no. 3  [PUBMED]    
4.Sciot R, Dal Cin P, Fletcher CD, Hernandez JM, Samson I, Ramos L, et al. Inflammatory myofibroblastic tumor of bone: Report of two cases with evidence of clonal chromosomal changes. Am J Surg Pathol 1997;21:1166-72.   Back to cited text no. 4  [PUBMED]  [FULLTEXT]  
5.Pungopapong S, Geiger JX, Raimondo M. Inflammatory myofibroblastic tumor presenting as a pancreatic mass: A case report and review of literature. J Pancreas 2004;5:360-7.   Back to cited text no. 5      
6.Jeon YK, Chang KH, Suh YL, Jung HW, Park SH. Inflammatory myofibroblastic tumor of the central nervous system: Clinicopathologic analysis of 10 cases. J Neuropathol Exp Neurol 2005;64:254-9.   Back to cited text no. 6  [PUBMED]  [FULLTEXT]  
7.Watanbe K, Tajino T, Sekiguchi M, Suzuki T. Inflammatory myofibroblastic tumor (inflammatory fibrosarcoma) of the bone. Arch Pathol Lab Med 2000;124:1514-7.  Back to cited text no. 7      
8.Gasparotti R, Zanetti D, Bolzoni A, Gamba P, Morassi LM, Ungari M. Inflammatory myofibroblastic tumor of the temporal bone. AJNR Am J Neuroradiol 2003;24:2092-6.   Back to cited text no. 8      
9.Cho AH, Lee BH, Kwak KW, Kang JK. Inflammatory pseudo tumor of temporal bone with pachymeningitis, cranial neuropathies and uveitis. Eur Neurol 2004;51:238-40.   Back to cited text no. 9  [PUBMED]  [FULLTEXT]  
10.Han MH, Chi JG, Kim MS, Chang KH, Kim KH, Yeon KM, et al. Fibrosing inflammatory pseudotumors involving the skull base: MR and CT manifestations with histopathologic comparison. AJNR Am J Neuroradiol 1996;17:515-21.  Back to cited text no. 10  [PUBMED]  [FULLTEXT]  

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Correspondence Address:
Nandita Ghosal
Department of Pathology and Transfusion Medicine, Sri Sathya Sai Institute of Higher Medical Sciences (SSSIHMS), Bangalore
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.68296

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  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

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