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Year : 2010  |  Volume : 53  |  Issue : 3  |  Page : 570
Comments: Siderophore production by uropathogenic Escherichia coli

Department Escherichia coli of Microbiology, Sir H. N. Hospital Medical Research Society, Mumbai, India

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Date of Web Publication22-Oct-2010

How to cite this article:
Gokarn K. Comments: Siderophore production by uropathogenic Escherichia coli. Indian J Pathol Microbiol 2010;53:570

How to cite this URL:
Gokarn K. Comments: Siderophore production by uropathogenic Escherichia coli. Indian J Pathol Microbiol [serial online] 2010 [cited 2021 Sep 21];53:570. Available from: https://www.ijpmonline.org/text.asp?2010/53/3/570/68243


I would like to comment on the article on 'Siderophore production by uropathogenic  Escherichia More Details coli' printed in your journal's issue of Jan-Mar 2009. [1]

I am carrying out comparative studies on siderophore production by organisms isolated from clinical specimens and commensals. I would like to bring to your notice that we have not found a significant difference in the siderophore production between clinical isolates and commensals. We have carried our qualitative as well as quantitative estimation of siderophores.

Therefore, one cannot use siderophore production as a determinant of virulence of an organism. Any bacteria will produce sufficient quantities of siderophore when grown in an iron-deficient environment when incubated at its optimum growth conditions.

Similar observations were published in the article Miles et al.,[2] where they observed that non-pathogenic as well as pathogenic Escherichia coli were active producers of siderophores.

This suggests that siderophore production may be a necessary feature of a virulent bacterium but not a determinant of virulence. The siderophore producing potential of a pathogen in vivo cannot be decided on the basis of in vitro tests.

   References Top

1.Vagrali MA. Siderophore production by uropathogenic Escherichia coli. Indian J Pathol Microbiol 2009;52:126-7.  Back to cited text no. 1  [PUBMED]  Medknow Journal  
2.Miles AA, Khimji PL. Enterobacterial chelators of iron: Their occurrence, detection and relation to pathogenecity. J Med Microbiol 1975;8:477-90.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]  

Correspondence Address:
Karuna Gokarn
Sir H.N. Hospital and Medical Research Society, Raja Rammohan Roy Road, Prarthana Samaj, Mumbai
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.68243

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1 Authoręs reply
Vagrali, M.A.
Indian Journal of Pathology and Microbiology. 2010; 53(3): 576


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