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Year : 2010  |  Volume : 53  |  Issue : 3  |  Page : 584-585
Corpora amylacea in prostatic stromal smooth muscle cells


1 Service d'Anatomie et de Cytologie Pathologiques, Centre Hospitalier de Lagny-Marne-La-Vallée, France
2 Department of General and Clinical Pathology, Medical University of Plovdiv, Plodiv, Bulgaria

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Date of Web Publication22-Oct-2010
 

How to cite this article:
Dikov D, Staribratova D, Belovejdov V. Corpora amylacea in prostatic stromal smooth muscle cells. Indian J Pathol Microbiol 2010;53:584-5

How to cite this URL:
Dikov D, Staribratova D, Belovejdov V. Corpora amylacea in prostatic stromal smooth muscle cells. Indian J Pathol Microbiol [serial online] 2010 [cited 2021 Sep 27];53:584-5. Available from: https://www.ijpmonline.org/text.asp?2010/53/3/584/68260


Sir,

We studied the involuntary patterns in the prostates of patients with debilitating disease, including patients who had died of acquired immune deficiency disease (AIDS). [1] During our study, we encountered an interesting finding of corpora amylacea in the prostatic smooth muscle stromal cells in two 35- and 39-year-old Caucasian males who died from overwhelming opportunistic infection leaving the gland injured.

Both the patients were cachectic. The prostate glands weighed 18 and 20 g, respectively, and histologically showed large areas of atrophy accompanied by sparse mononuclear inflammatory reaction. In the atrophic smooth muscle cells of the peripheral zone, eosinophilic spherical laminated bodies measured 15 ΅m in diameter were found to lie perpendicular to the long axis of the cell [Figure 1]a.

Their specific concentric lines stained intensively with phosphotungstic acid hematoxylin (PTAH) [Figure 1]b. These oval bodies were intimately related to the cytoplasm of the smooth muscle cells and stained weakly with alpha-smooth muscle actin [Figure 1]c.
Figure 1: Corpora amylacea in the prostati c smooth muscle stromal cells. (a) Hematoxylin and eosin stain (original magnifi cati on, ×200), (b) PTAH (original magnifi cati on, ×400), (c) peripheral staining with alpha-smooth muscle actin (SMA) (original magnification, ×200), (d) hyaline bodies in atrophic smooth muscle stromal cells: hematoxylin– phloxine– saff ron stain (original magnifi cati on, ×200)

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The nuclei of the neighbouring muscle fibers were shrunken with condensed chromatin and the cytoplasm contained varying numbers of hyaline bodies [Figure 1]d. Prostatic corpora amylacea are almost always intraluminal, laminated secretions that are commonly present in the prostatic glands and increase in prevalence with advancing age. They are noncellular structures of a glucoprotein nature and are thought to be related to epithelial cell degeneration, perhaps secondary to chronic prostatitis. In the last few years, a link between bacterial infection, inflammation and amyloid deposition of proinflammatory proteins S100A8/A9 was reported in the prostate gland such that a self-perpetuating cycle can be triggered and may increase the risk of malignancy in the ageing prostate. [2]

To the best of our knowledge, the prostatic corpora amylacea have never been reported in a stromal location. The development of smooth muscle hyaline bodies has been described in the wall of the seminal vesicle, which is poorly studied in prostatic stroma. [2,3] In the pre-AIDS period, Kovi et al.[4] described similar changes in the prostatic stroma in a 37-year-old Nigerian man who died from acute renal tubular injury with unclear etiology. The significance and the morphogenesis of these bodies are still unknown. They seem to arise from the degeneration and atrophy of the smooth muscle fibers in the conditions of general and organ atrophy in debilitating and probably many other conditions.

 
   References Top

1.Dikov DI, Roland J, Chatelet FP, Cywiner-Golenzer C. An autopsy study of the prostate in acquired immunodeficiency syndrome: Evidence for excessive apoptosis and intracytoplasmic epithelial inclusions. Arch Pathol Lab Med 1998;122:875-9.  Back to cited text no. 1  [PUBMED]    
2.Yanamandra K, Alexeyev O, Zamotin V, Srivastava V, Shchukarev A, Brorsson AC, et al. Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate. PLoS ONE 2009;4:e5562.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]  
3.Kuo T, Gomez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg Pathol 1981;5:483-90.  Back to cited text no. 3  [PUBMED]    
4.Kovi J, Jackson MA, Akberzie ME. Unusual smooth muscle changes in the prostate. Arch Pathol Lab Med 1979;103:204-5.  Back to cited text no. 4  [PUBMED]    

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Correspondence Address:
Diana Staribratova
Department of Pathology, Medical University of Plovdiv, 4000 Plovdiv
Bulgaria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.68260

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