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Indian Journal of Pathology and Microbiology
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CASE REPORT
Year : 2011  |  Volume : 54  |  Issue : 3  |  Page : 591-593

Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype


1 Department of Pathology, Tata Memorial Hospital, Mumbai, India
2 Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, India
3 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Correspondence Address:
Tanuja Shet
Department of Pathology, 8th Floor, Annex Building, Tata Memorial Hospital, Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.85104

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Primary cardiac lymphoma (PCL) is a rare and fatal disorder. It may often mimic other common cardiac tumors like cardiac myxoma because of similarities in the clinical presentation. We report a case of PCL of diffuse large B-cell type, in a 38-year-old, immunocompetent male who presented with superior vena cava syndrome that was excised as a myxoma. Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype. After four cycles of Rituximab with CHOP (cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisolone) the tumor regressed completely but the patient had a relapse and subsequently succumbed to the disease confirming the aggressive nature. The aggressive behavior of PCL may be possibly linked to its ABC-like origin.


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