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Indian Journal of Pathology and Microbiology
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CASE REPORT
Year : 2011  |  Volume : 54  |  Issue : 3  |  Page : 599-602

Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma


Hematopathology of Laboratory, Tata Memorial Hospital, Mumbai, India

Correspondence Address:
Sumeet Gujral
Hematopathology of Laboratory, 727, Annex Building, Tata Memorial Hospital, Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0377-4929.85108

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Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.


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