Indian Journal of Pathology and Microbiology
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Year : 2011  |  Volume : 54  |  Issue : 3  |  Page : 609-611

Transfusion-induced hemoglobinopathy in patients of beta-thalassemia major

Department of Haematology, IRCH Building, 1st Floor, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

Correspondence Address:
Sanjeev K Gupta
B-1/226, Yamuna Vihar, Delhi - 110 053
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.85112

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Apparent hemoglobinopathy acquired after blood transfusion is an uncommon cause of diagnostic dilemma resulting in repeated testing and delay in the diagnosis. Out of the 1530 hemoglobin (Hb)- high-performance liquid chromatography (HPLC) performed at our hospital (May 2009 to April 2010), 3 pediatric cases of thalassemia major were detected having posttransfusion hemoglobinopathy with HbS ranging from 9.9% to 18.5%. In all three cases, there was no variant hemoglobin in earlier documented Hb-HPLC. It is important to be aware of and consider apparent transfusion-induced hemoglobinopathy in patients with unusual percentage of variant hemoglobin to avoid unnecessary treatment and counseling.

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