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Year : 2011  |  Volume : 54  |  Issue : 4  |  Page : 853-854
Differential diagnosis of oncocytic pleomorphic adenoma

Department of Oral Histopathology, Hainan Medical College, Longhua District, Haikou, China

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Date of Web Publication6-Jan-2012

How to cite this article:
Yang S. Differential diagnosis of oncocytic pleomorphic adenoma. Indian J Pathol Microbiol 2011;54:853-4

How to cite this URL:
Yang S. Differential diagnosis of oncocytic pleomorphic adenoma. Indian J Pathol Microbiol [serial online] 2011 [cited 2022 May 18];54:853-4. Available from: https://www.ijpmonline.org/text.asp?2011/54/4/853/91527


I read with great interest the recent case report by Mariano et al. [1] The authors report a unique case of oncocytic pleomorphic adenoma (PA) of the parotid gland. However, the authors have omitted an important differential diagnosis, namely, oncocytic epithelial-myoepithelial carcinoma (EMC).

Oncocytic EMC was a recently described variant of EMC and this entity should be included in the differential diagnosis of oncocytic tumors of salivary glands. [2],[3],[4] With reference to this case reported by Mariano et al., [1] a biphasic nature of the tumor was confirmed by histopathology and immunohistochemistry. Both oncocytic PA and oncocytic EMC should be considered. Distinguishing features from PA include documentation of invasion and the absence of chondromyxoid stroma in EMC. However, this case was devoid of chondromyxoid stroma, which was usually seen in previously reported oncocytic PA. [5] Although an evident capsule was noted by the authors, it should be kept in mind that at least partial encapsulation in EMC is relatively common and complete encapsulation with minimal invasion was seen in 19.7% EMCs. [3] Therefore, a careful examination of invasion is required to exclude oncocytic EMC before a diagnosis oncocytic PA is made.

   References Top

1.Mariano FV, Vidaurre EC, Bologna-Molina RE, Carlos-Bregni R, Paes de Almeida O. Histopathological and immunohistochemical analysis of oncocytic pleomorphic adenoma. Indian J Pathol Microbiol 2011;54:193-5.  Back to cited text no. 1
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2.Savera AT, Salama ME. Oncocytic epithelial-myoepithelial carcinoma of the salivary gland: An underrecognized morphologic variant. Mod Pathol 2005;18(Suppl. 1);217A.  Back to cited text no. 2
3.Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma: A review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol 2007;31:44-57.  Back to cited text no. 3
4.Antic T, Venkataraman G, Oshima K. Oncocytic epithelial-myoepithelial carcinoma: An evolving new variant with comparative immunohistochemistry. Pathology 2008;40:415-8.  Back to cited text no. 4
5.Di Palma S, Lambros MB, Savage K, Jones C, Mackay A, Dexter T, et al. Oncocytic change in pleomorphic adenoma: Molecular evidence in support of an origin in neoplastic cells. J Clin Pathol 2007;60:492-9.  Back to cited text no. 5

Correspondence Address:
Shaodong Yang
Department of Oral Histopathology, Hainan Medical College, 3 Xueyuan Road, Longhua District, Haikou
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.91527

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Mariano, F.V., Vidaurre, E.C., Bologna-Molina, R.E., Carlos-Bregni, R., Paes De Almeida, O.
Indian Journal of Pathology and Microbiology. 2011; 54(4): 854


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