Indian Journal of Pathology and Microbiology
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Year : 2012  |  Volume : 55  |  Issue : 3  |  Page : 419-420
Nevus sebaceous at unusual location: A rare presentation

1 Pathology Deparment, Uludag University Medical Faculty, Bursa, Turkey
2 Obstetrics and Gynecology Deparment, Uludag University Medical Faculty, Bursa, Turkey

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Date of Web Publication29-Sep-2012

How to cite this article:
Ugras N, Ozgun G, Adim SB, Ozerkan K. Nevus sebaceous at unusual location: A rare presentation. Indian J Pathol Microbiol 2012;55:419-20

How to cite this URL:
Ugras N, Ozgun G, Adim SB, Ozerkan K. Nevus sebaceous at unusual location: A rare presentation. Indian J Pathol Microbiol [serial online] 2012 [cited 2020 Nov 30];55:419-20. Available from: https://www.ijpmonline.org/text.asp?2012/55/3/419/101768


Nevus sebaceous (NS) is a benign skin lesion that occurs most frequently on the scalp (59.3%) and less often on the face, preauricular area, and the head and neck region. NS can rarely be identified in other locations, such as the trunk or the oral mucosa. [1],[2] Herein, we present a case with NS located in the genital region, which has been reported only in one case in the literature.

A 42-year-old healthy female was admitted with a slightly enlarged, sometimes pruritic lesion in genital localization. The lesion had been present for the last 2 years. A vulvar biopsy performed at another institution was reported as squamous hyperplasia. At the time of admission to our institution, a yellowish-tan lobulated growth lesion, measuring approximately 1 cm in diameter was detected in vulva. General physical examination and routine laboratory parameters were normal. The vulvar biopsy was repeated.

Histopathological examination revealed large numbers of mature sebaceous glands, marked papillomatosis with hyperkeratosis, and acanthosis of the epidermis [Figure 1]. In the dermis, sebaceous glands were connected to the overlying epidermis . The histopathological features were consistent with those of NS. The patient is on regular follow-up and there has been no recurrence for 10 months after the surgery.
Figure 1: Slight hyperkeratosis, papillomatosis, and acanthosis with enlarged sebaceous glands haematoxylin and eosin, × 40)

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To the best of our knowledge, this is the second reported case of NS in the genital region. [3]

The clinical differential diagnosis of NS located in the genital region includes condyloma acuminatum, condyloma latum, inflammatory conditions, such as furuncles, and, most importantly, vulvar neoplasms. By contrast, the histopathological differential diagnosis includes ectopic sebaceous glands (Fordyce's granules or spots), sebaceous adenoma, and sebaceoma. Fordyce's spots consist of a group of small sebaceous duct extending not to the surface epithelium. Sebaceous adenomas are composed of incompletely differentiated lobules, sharply demarcated from the surrounding tissue. There are two types of cells in the lobules. The first type is identical to the cells at the periphery of normal sebaceous glands and the second is mature sebaceous cells. Sebaceoma is composed of undifferentiated basaloid cells with islands of sebaceous cells and sebaceous ducts. In sebaceous hyperplasia, ductal structures are more apparent than in NS. [4]

In conclusion, our case was unusual because of the genital location of NS, which has been reported in one case previously. Labia minora may be considered the second mucosal site after the oral mucosa, where NS can involve. [3]

   References Top

1.Cribier B, Scrivener Y, Grosshans E. Tumors arising in nevus sebaceus: a study of 596 cases. J Am Acad Dermatol 2000;42:263-8.  Back to cited text no. 1
2.Morency R, Labelle H. Nevus sebaceus of Jadassohn:a rare oral presentation. Oral Surg Oral Med Oral Pathol 1987;64:460-2.  Back to cited text no. 2
3.Kavak A, Ozcelik D ,Belenli O, Buyukbabani N, Saglam I, Lazova R. A unique location of naevus sebaceus: labia minora. J Eur Acad Dermatol Venerol 2008;22:1136-8.  Back to cited text no. 3
4.Ahmed TSS, Priore JD, Seykora JT. Tumors of the epidermal appendages. In: Elder DE, editor. Lever's histopathology of the skin, 10th ed. Philadelphia: Lippincott Williams and Wilkins; 2009. p. 870-4.  Back to cited text no. 4

Correspondence Address:
Nesrin Ugras
Department of Pathology, Uludag University, Gorukle, Bursa 16059
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.101768

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