Indian Journal of Pathology and Microbiology
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Year : 2012  |  Volume : 55  |  Issue : 4  |  Page : 521-524

Pediatric gliosarcoma with fibrosarcomatous differentiation: Report of a rare case

1 Department of Pathology, Institute of Neurology, Madras Medical College, Chennai, India
2 Department of Pathology, Institute of Pathology, Madras Medical College, Chennai, India
3 Department of Medical Oncology, Madras Medical College, Chennai, India

Correspondence Address:
Shantha Ravisankar
Department of Pathology, Institute of Neurology, Madras Medical College, Chennai - 600 003
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.107797

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Gliosarcoma is a rare variant of glioblastoma with a biphasic pattern showing glial and mesenchymal differentiation. It is seen in adults during their fifth to sixth decades of life and is extremely rare in children. We report a case of primary gliosarcoma with fibrosarcomatous differentiation in an 11-year-old boy presenting with headache and vomiting. Imaging showed a contrast-enhancing isodense space-occupying lesion with areas of calcification in the right temporoparietal cortex. A total excision was done and, on histopathologic examination, a differential diagnostic consideration of gliosarcoma and teratoma with malignant transformation was made. After immunohistochemical analysis, a final diagnosis of gliosarcoma with fibrosarcomatous differentiation was then made. Primary gliosarcoma is a very rare tumor in children with a poor prognosis.

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