Indian Journal of Pathology and Microbiology
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Year : 2014  |  Volume : 57  |  Issue : 1  |  Page : 127-129

Cutaneous amyloidosis at the site of insulin injection with coexistence of acanthosis nigricans

1 Department of Pathology, St. John's Medical College, Bengaluru, Karnataka, India
2 Department of Dermatology, St. John's Medical College, Bengaluru, Karnataka, India

Correspondence Address:
Bevinahalli N Nandeesh
Department of Pathology, St. John's Medical College, John Nagar, Bengaluru - 560 034, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.130920

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Skin is one of the important organs affected by amyloidosis which is characterized by extracellular deposition of fibrillary proteins having homogenous, eosinophilic on routine staining with distinct tinctorial properties. Nodular cutaneous amyloidosis is rare and may affect dermis, subcutis and also vascular walls. Nodular amyloid deposits in the deeper dermis occurring at the site of insulin injection are a rare observation, which is described here. This description indicates that cutaneous amyloidosis may be associated with local subcutaneous injections of insulin and may clinically mimic a neoplasm or lipodystrophic lesion.

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