| CASE REPORT |
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| Year : 2014 | Volume
: 57
| Issue : 2 | Page : 294-297 |
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Large cell/anaplastic medulloblastoma with myogenic, melanotic and neuronal differentiation: A case report of a rare tumor
Amany A. Fathaddin1, Eman A. Bakhash2, Abdulrahman J. Sabbagh3, Sadeq W. Al-Dandan4
1 Department of Pathology, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia
2 Department of Radiology, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
3 Department of Neurosurgery, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
4 Department of Pathology, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
Correspondence Address:
Amany A. Fathaddin
Department of Pathology, King Khalid University Hospital, King Saud University, P.O. Box 241051, Riyadh 11322, Kingdom of Saudi Arabia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0377-4929.134722
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Medulloblastoma is an embryonal neuroepithelial tumor of the cerebellum and is the most common malignant central nervous system tumor in children. Different histological variants and patterns have been described. The classic variant represents the majority of cases. This report describes a rare case of large cell/anaplastic medulloblastoma with myogenic, melanotic and neuronal differentiation arising in the cerebellum of a 3-year-old boy who presented with headache and vomiting. Magnetic resonance imaging demonstrated a heterogeneously enhanced lesion in the fourth ventricle. Surgical resection of the tumor was accomplished, but a residual tumor was left behind because of the involvement of the brainstem. Postoperatively, the patient received chemotherapy and radiotherapy. Currently, 20 months after treatment, the patient has survived without further progression. Pathological examination revealed a high grade primitive neuronal tumor with foci of myogenic features, melanin containing epithelial elements and ganglion-like cells, which were confirmed by immunohistochemistry. |
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