Indian Journal of Pathology and Microbiology
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Year : 2014  |  Volume : 57  |  Issue : 2  |  Page : 320-322

Plasmacytoid urothelial carcinoma of the bladder

1 Department of Urology, Rizhao People's Hospital, Rizhao, China
2 Department of Pathology, Rizhao People's Hospital, Rizhao, China
3 Department of Pathology, Peking University First Hospital; Institute of Urology, Peking University, Beijing, China

Correspondence Address:
Gangping Wang
Department of Pathology, Rizhao People's Hospital, 126 Taian Road, Rizhao, Shandong province, 276826
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.134730

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Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is an uncommon and aggressive variant of urothelial carcinoma associated with late presentation and poor prognosis. Immunohistochemical examination showing expression of epithelial markers, CD138, and losing the membranous expression of E-cadherin confirms evidence of PUC. Here, we report a case of bladder PUC of a 74-year-old male who presented with hematuria. A transurethral biopsy revealed urothelial carcinoma with plasmacytoid appearance. The diagnostic dilemmas of this unusual variant of urothelial malignancy and its clinical impact are discussed. The pathological diagnosis was PUC (High-grade, pT4N2M0) with diffuse muscle, small tracts, and vascular invasion, in which almost of the areas studied on the tissue section showed Plasmacytoid differentiation.

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