Indian Journal of Pathology and Microbiology
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Year : 2014  |  Volume : 57  |  Issue : 4  |  Page : 549-552

Immunohistochemical expression of Insulin-like growth factor-1, Transforming growth factor-beta1, and Vascular endothelial growth factor in parathyroid adenoma and hyperplasia

1 Department of Pathology, Kahramanmaras Sutcu İmam University Faculty of Medicine, Kahramanmaras, Turkey
2 Department of Endocrinology, Kahramanmaras Sutcu İmam University Faculty of Medicine, Kahramanmaras, Turkey
3 Basic Oncology, Hacettepe University Ankara, Turkey
4 Department of Physiology, Kahramanmaras Sutcu İmam University Faculty of Medicine, Kahramanmaras, Turkey

Correspondence Address:
Hamide Sayar
Department of Pathology, Kahramanmaras Sutcu Imam University Faculty of Medicine, Avsar yerleskesi, Kahramanmaras, 46000
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.142658

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Background: Insulin-like growth factor (IGF), transforming growth factor-beta1 (TGF-β1), and vascular endothelial growth factor (VEGF) are commonly studied growth factors, but little data are available on the immunohistochemical expression of these factors in parathyroid lesions. Materials and Methods: Tissue specimens from 36 patients with primary hyperparathyroidism (P-HPT) (26 adenomas and 10 primary hyperplasias) were examined. Normal parathyroid tissue adjacent to the adenoma or area of hyperplasia was used as control tissue. Preoperative laboratory testing [serum Ca and P, creatinine and parathormone levels (PTH)] which led to the diagnosis of P-HPT had been performed, the size and weight of the parathyroid glands measured, and postoperative serum PTH levels determined. Paraffin-embedded parathyroid tissue specimens were stained with antibodies to IGF-1, VEGF, and TGF-β1 using standard immunohistochemical procedures. Results: IGF-1 immunoreactivity was seen in 50% of hyperplasia and in 46% of adenoma samples, but in 87% of normal parathyroid tissue in the vicinity of the adenomas (P = 0.005). TGF-β1 immunoreactivity was observed in 90% of hyperplasia, in 92% of adenoma samples, and in 95% of normal tissues around adenomas. VEGF immunoreactivity was observed in 70% of hyperplastic and 65% of adenomatous tissues, as well as in 54% of normal tissues in the vicinity of the adenoma. No significant differences in the expression of IGF-1, TGF-β1, and VEGF were observed between primary adenomas compared to hyperplasia samples (P > 0.05). Conclusions: Parathyroid tissue is clearly a site for production of IGF-1, TGF-β1, and VEGF. IGF-1 receptor activity was higher in normal parathyroid tissue compared to hyperplastic and adenomatous tissue.

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