Indian Journal of Pathology and Microbiology
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Year : 2015  |  Volume : 58  |  Issue : 2  |  Page : 214-216

Primary Merkel cell carcinoma of the oral mucosa in a young adult male: Report of a rare case

1 Department of Pathology and Medical Oncology, Saroj Gupta Cancer Centre and Research Institute, Kolkata, West Bengal, India
2 Medical College, Kolkata, West Bengal, India

Correspondence Address:
Dr. Ayandip Nandi
48/7, Patuapara Lane, P.O. Serampore, Hooghly - 712 201, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.155318

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Merkel cell carcinoma (MCC) is a highly aggressive neoplasm of skin with neuroendocrine differentiation. Primary MCC of the oral mucosa is exceedingly rare and even more unresponsive to therapy. A 15-year-old male presents with gradually increasing painless swelling in right side of the floor of mouth for 6 weeks. Computed tomography of head and neck region showed globular mass (4.6 cm × 1.7 cm) involving right side of the floor of mouth. Fine-needle aspiration from the upper deep cervical node suggested small round cell tumor. A trucut biopsy showed mass composed of trabeculae and nests of tumor cells with high N:C ratio, granular speckled chromatin, scanty to moderate amount of clear vacuolated cytoplasm. Cells were immunoreactive for cytokeratin-20, CD56, c-kit, CD99 and negative for p63, thyroid-transcription factor-1, CDX2, synaptophysin, neuron-specific enolase. Patient was started on chemotherapy with cyclophosphamide, doxorubicin and vincristine. The mass regressed in size and patient underwent wide local excision with pull-through approach. Patient is currently under combined chemoradiation regime and doing well.

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