Indian Journal of Pathology and Microbiology
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Year : 2015  |  Volume : 58  |  Issue : 2  |  Page : 232-234

Adenocarcinoma of the rete testis with prominent papillary structure and clear neoplastic cells: Morphologic and immunohistochemical findings and differential diagnosis

Department of Pathology, Mackay Memorial Hospital, Hsinchu, Taiwan, Republic of China

Correspondence Address:
Dr. Kuo-Ming Chang
Department of Pathology, Mackay Memorial Hospital, No. 690, Sec. 2, Guangfu Rd, East Dist, Hsinchu City 30071, Taiwan
Republic of China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.155328

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Adenocarcinoma of the rete testis is rare, and its etiology is unknown. The definite diagnosis merely depends on the exclusion of other tumors and histological features. We first describe a 38-year-old man with a carcinoma arising in the rete testis. The tumor was characterized by clear neoplastic cells and branching papillary growth. Focal stromal invasion and transition of normal rete epithelium to neoplastic cells were seen. The neoplastic cells were positive for epithelial membrane antigen, Ber-Ep4, vimentin, renal cell carcinoma marker, and CD10, while negative for Wilms' tumor 1, thyroid transcription factor-1, estrogen receptor, prostate specific antigen, placental alkaline phosphate, CD117, and alpha-1-fetoprotein. According to the above features, we diagnosed this tumor as adenocarcinoma of the rete testis. To our best knowledge, this is the first reported case of adenocarcinoma of the rete testis with prominently papillary structure and clear neoplastic cells. The rarity of adenocarcinoma of the rete testis and the unique features in our case cause diagnostic pitfalls. A complete clinicopathological study and thorough differential diagnosis are crucial for the correct result.

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