Indian Journal of Pathology and Microbiology
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Year : 2015  |  Volume : 58  |  Issue : 4  |  Page : 550-553

Lymphoepithelioma-like hepatocellular carcinoma without Epstein-Barr virus infection: A case report and a review of the literature

1 Department of Pathology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang Province, China
2 Department of Pathology, Shaoxing No. 2 Hospital, Shaoxing, Zhejiang Province, China

Correspondence Address:
Dr. Jianguo Wei
Department of Pathology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, No.568 Zhongxing North Road, Shaoxing District, 312000 Shaoxing, Zhejiang Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.168857

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Lymphoepithelioma-like carcinoma (LELC) of the liver is uncommon, only 20 cases have been reported in the English-language literature so far, and the majority has been identified as cholangiocarcinomas, only four cases were hepatocellular LELC. Here we described a rare case of lymphoepithelioma-like hepatocellular carcinoma (HCC). A 42-year-old Chinese female who was incidentally found to have a liver-occupying lesion during a routine medical examination. Ultrasonography revealed a 47 mm × 33 mm × 36 mm hypoechoic mass in the left lobe. Computed tomography and magnetic resonance imaging displayed a nodular lesions in the left liver lobe. The patient underwent a left-side hepatectomy. Histopathological examination of the resected specimen revealed an undifferentiated carcinoma with a dense lymphocytic infiltrate, predominantly composed of CD3(+) T cells, morphologically similar to nasopharyngeal carcinoma. Immunohistochemically, the tumor cells were positive for CK, EMA, Glypican-3 and hepatocyte, but negative for alpha-fetoprotein, CK19, CK7 and CK20. Epstein–Barr virus (EBV) in situ hybridization was negative. The final histopathological diagnosis was lymphoepithelioma-like HCC without EBV infection.

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