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| Year : 2016 | Volume
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| Issue : 2 | Page : 141-142 |
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| From Editor's desk |
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Vatsala Misra
Editor-in Chief, IJPM, Professor and Head, Department of Pathology, MLN Medical College, Allahabad, Uttar Pradesh, India
Click here for correspondence address and email
| Date of Web Publication | 9-May-2016 |
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How to cite this article:
Misra V. From Editor's desk. Indian J Pathol Microbiol 2016;59:141-2 |
Dear Readers,
After initial delay, I am glad to present before you the second issue of IJPM 2016 in time. In this issue we have tried to cover the every aspect of pathology varying from morphology to molecular biology and from diagnostic to prognostic markers so that the articles may be of interest to the readers from different fields.
Survivin, a newly described protein belongs to a family of proteins known as the inhibitor of apoptosis proteins (IAPs). These IAPs are crucial regulator of the molecular mechanisms involved in apoptosis. Over expression of survivin has oncogenic potential and has prognostic significance as aberrantly expressed survivin and STAT3 signalling have emerged as major determinants of chemo-resistance and more aggressive tumor and poor prognosis in cancers like stomach,[1] colon,[2] and breast.[3] Recently effect of herbal derivatives like curcumin, berberine and quercetin on STAT3 signalling, survivin expression and response to 5-fluorouracil has been studied (5-FU) treatment in gastric cancer cells (AGS). as adjunct therapeutics to overcome chemo-resistance during treatment of gastric malignancies.[4] Gupta et al. in their article in this issue have found significantly higher expression of survivin protein in gallbladder cancer as compared to non neoplastic lesions suggesting its role in gallbladder carcinogenesis.[5]
Human immunodeficiency virus (HIV) infection has been prevalent for over three decades in India; an increasing number of children are being affected with HIV. The spectrum of pathologic lesions in children with acquired immunodeficiency syndrome (AIDS) in India has not been well described. The study by Lanjewar et al. provides an insight into the spectrum of pathologic lesions in children with AIDS in India. TB and CMV infection has been found to be the most prevalent infection in our children [6]
Tuberculosis is one of the commonest infections encountered in India. Clinical presentation of Mycobacterium tuberculosis complex (MTBC) and non-tuberculous mycobacteria (NTM) infections may be similar but treatment is always different.[7] NTM are inherently resistant to conventional anti-tuberculosis drugs, hence often misdiagnosed as multidrug resistant tuberculosis hence, accurate differentiation between MTBC and NTM is important for proper treatment of the patients.[7] As the conventional phenotypic identification methods are cumbersome, and genotypic methods require expertise and substantial monetary and infrastructural investment, recently devised TBMPT64 antigen based immunochromatography assays offer promise in rapid and cost-effective differentiation. Nerurkar et al. in their study in this issue have tried to demonstrate in parallel the importance of assessment of a commercial MPT64 ICT and bacillary morphology on liquid culture smear, for rapid differentiation between MTBC and NTM in clinical isolates.[8]
Besides this there are number of original article, interesting case reports and images that may help the young pathologists in enhancing their knowledge.
I once again request all the senior members to contribute review articles in their field of expertise and also to new columns such as a quiz, clinicopathological conference, or 'How I do it' for the benefit of our budding pathologist.
With best wishes
 References | |  |
| 1. | Lee GH, Joo YE, Koh YS, Chung IJ, Park YK, Lee JH, et al. Expression of survivin in gastric cancer and its relationship with tumor angiogenesis. Eur J Gastroenterol Hepatol 2006;18:957-63.  |
| 2. | Huang YJ, Qi WX, He AN, Sun YJ, Shen Z, Yao Y. The prognostic value of survivin expression in patients with colorectal carcinoma: A meta-analysis. Jpn J Clin Oncol 2013;43:988-95. |
| 3. | Song J, Su H, Zhou YY, Guo LL. Prognostic value of surviving expression in breast cancer patients: A meta-analysis. Tumour Biol 2013;34:2053-62. |
| 4. | Pandey A, Vishnoi K, Mahata S, Tripathi SC, Misra SP, Misra V, Mehrotra R, Dwivedi M, Bharti AC Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard hemotherapeutic 5-Fluorouracil. Nutrition and Cancer. 2015;1:12. DOI: 10.1080/01635581.2015.1085581 |
| 5. | Gupta V, Goel M M, Chandra A, Gupta P, Kumar S, Nigam J Expression and clinicopathological significance of antiapoptotis protein survivin in gallbladder cancer. IJPM 2016. |
| 6. | Lanjewar DN, Bhatia VO, Lanjewar SD Pathologic lesions in children with acquired immunodeficiency syndrome an autopsy study of 11 cases from Mumbai, India IJPM 2016. |
| 7. | Kanade S, Nataraj G, Suryawanshi R, Mehta P. Utility of MPT 64 antigen detection assay for rapid characterization of mycobacteria in a resource constrained setting. Indian J Tuberc 2012;59:92-6. |
| 8. | Nerurkar V, Kattungal S, Bhatia S Utility of MPT64 antigen test for differentiating mycobacteria: Can correlation with liquid culture smear morphology add further value? IJPM 2016. |
Correspondence Address:
Vatsala Misra
Editor-in Chief, IJPM, Professor and Head, Department of Pathology, MLN Medical College, Allahabad, Uttar Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0377-4929.182046
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