Indian Journal of Pathology and Microbiology
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Year : 2016  |  Volume : 59  |  Issue : 2  |  Page : 172-176

Clinicopathological characteristics of patients of certain molecular subtypes and elevated postoperative cancer antigen 15.3 levels and its correlation with menopausal status

1 Department of General Surgery, IPGME and R/SSKMH, Kolkata, West Bengal, India
2 Department of Pharmacology, IPGME and R/SSKMH, Kolkata, West Bengal, India

Correspondence Address:
Soumi Saha
Senior Research Scholar, Department of General Surgery, IPGMER, 244, A.J.C. Bose Road, Kolkata, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0377-4929.182029

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Context: It is well established that breast cancer subtypes differ in their outcome and treatment response. Aim: To observe tumor characteristics of different molecular subgroup and patients with postoperative (PO) raised cancer antigen 15.3 (CA 15.3) group and variation of tumor nature between pre- and post-menopausal breast cancer patients. Materials and Methods: Blood samples and tumor blocks were collected from 95 nonmetastatic female breast cancer patients. Immunohistochemical stains for estrogen receptors (ER), progesterone receptor (PR), and HER2/Neu were used to classify molecular subtypes. CA 15.3 level was detected by ELISA. Significance levels were ascertained by Pearson Chi-square test. Results: Prevalence of luminal A tumor with grade 3 was high. Triple negative and ER positive (ER+) types showed tumors with high grade and high lymph node (LN) metastasis. More nodal involvement was noticed in patients with PO raised CA 15.3. In addition, premenopausal patients with triple-negative and ER+ subtypes exhibited more aggressive tumors which were characterized by high grade and large numbers of LN metastasis. Conclusion: Clinicopathological characteristics of certain molecular subtypes and influence of menopausal status on it can predict disease recurrence or overall survival of breast cancer patients.

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